Limbic hyperconnectivity in the vegetative state

[en] Objective: To investigate functional connectivity between the default mode network (DMN) and other networks in disorders of consciousness. Methods: We analyzedMRI data from 11 patients in a vegetative state and 7 patients in a minimally conscious state along with age- And sex-matched healthy control subjects. MRI data analysis included nonlinear spatial normalization to compensate for disease-related anatomical distortions. We studied brain connectivity data from resting-state MRI temporal series, combining noninferential (independent component analysis) and inferential (seed-based general linear model) methods. Results: In DMN hypoconnectivity conditions, a patient's DMN functional connectivity shifts and paradoxically increases in limbic structures, including the orbitofrontal cortex, insula, hypothalamus, and the ventral tegmental area. Conclusions: Concurrently with DMN hypoconnectivity, we report limbic hyperconnectivity in patients in vegetative and minimally conscious states. This hyperconnectivity may reflect the persistent engagement of residual neural activity in self-reinforcing neural loops, which, in turn, could disrupt normal patterns of connectivity.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Di Perri, Carol

Bastianello, Stefano

Bartsch, Andreas Joachim

Pistarini, Caterina

Maggioni, Giorgio

Magrassi, Lorenzo

Imberti, Roberto

Pichiecchio, Anna

Vitali, Paolo

Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron

Di Salle, Francesco

Language :

English

Title :

Limbic hyperconnectivity in the vegetative state

Publication date :

October 2013

Journal title :

Neurology

ISSN :

0028-3878

eISSN :

1526-632X

Publisher :

Lippincott Williams & Wilkins, Hagerstown, United States - Maryland

Volume :

Vol 81

Pages :

1417-1424

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 August 2014

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