Article (Scientific journals)
Abnormal corticospinal excitability in patients with disorders of consciousness
Lapitskaya, Natallia; Gosseries, Olivia; DE PASQUA, Victor et al.
2013In Brain Stimulation, Volume 6, p. 590-597
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Keywords :
Vegetative state; Unresponsive wakefulness syndrome; Minimally conscious state; Brain injury; Transcranial magnetic stimulation; Motor evoked potentials; Somatosensory evoked potentials; Short latency afferent inhibition
Abstract :
[en] Background: Transcranial magnetic stimulation (TMS) has been frequently used to explore changes in the human motor cortex in different conditions, while the extent of motor cortex reorganization in patients in vegetative state (VS) (now known as unresponsive wakefulness syndrome, UWS) and minimally conscious (MCS) states due to severe brain damage remains largely unknown. Objective/hypothesis: It was hypothesized that cortical motor excitability would be decreased and would correlate to the level of consciousness in patients with disorders of consciousness. Methods: Corticospinal excitability was assessed in 47 patients (24 VS/UWS and 23 MCS) and 14 healthy controls. The test parameters included maximal peak-to-peak M-wave (Mmax), F-wave persistence, peripheral and central motor conduction times, sensory (SEP) and motor evoked (MEP) potential latencies and amplitudes, resting motor threshold (RMT), stimulus/response curves, and short latency afferent inhibition (SAI). TMS measurements were correlated to the level of consciousness (assessed using the Coma Recovery Scale-Revised). Results: On average, the patient group had lower Mmax, lower MEP and SEP amplitudes, higher RMTs, narrower stimulus/response curves, and reduced SAI compared to the healthy controls (P < 0.05). The SAI alterations were correlated to the level of consciousness (P < 0.05). Conclusions: The findings demonstrated the impairment of the cortical inhibitory circuits in patients with disorders of consciousness. Moreover, the significant relationship was found between cortical inhibition and clinical consciousness dysfunction.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Lapitskaya, Natallia 
Gosseries, Olivia   ;  Université de Liège - ULiège > Centre de recherches du cyclotron
DE PASQUA, Victor ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Pedersen, AR
Nielsen
MAERTENS DE NOORDHOUT, Alain  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
 These authors have contributed equally to this work.
Language :
English
Title :
Abnormal corticospinal excitability in patients with disorders of consciousness
Publication date :
July 2013
Journal title :
Brain Stimulation
ISSN :
1935-861X
eISSN :
1876-4754
Publisher :
Elsevier, New York, United States - New York
Volume :
Volume 6
Pages :
590-597
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 August 2014

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