complex diseases; genetic influence; human; hypothesis-driven approach; hypothesis-independent manner; immunoglobulin E; mouse; multiple interacting genes; mutation in a single gene; serum level
Abstract :
[en] Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody.
Disciplines :
Genetics & genetic processes
Author, co-author :
Gusareva, Elena ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Kurey, Irina; Institute of Molecular Genetics > Molecular and Cellular Immunolofy
Grekov, Igor; Institute of Molecular Genetics > Molecular and Cellular Immunolofy
Lipoldova, Marie; Institute of Molecular Genetics > Molecular and Cellular Immunolofy
Language :
English
Title :
Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Publication date :
May 2014
Journal title :
Biological Reviews
ISSN :
1464-7931
eISSN :
1469-185X
Publisher :
Blackwell Publishing, New York, United States - New York
Aalberse, R. C. & Platts-Mills, T. A. (2004). How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective. The Journal of Allergy and Clinical Immunology 113, 983-986.
Abboud, G., Staumont-Salle, D., Kanda, A., Roumier, T., Deruytter, N., Lavogiez, C., Fleury, S., Remy, P., Papin, J. P., Capron, M. & Dombrowicz, D. (2009). Fc(epsilon)RI and FcgammaRIII/CD16 differentially regulate atopic dermatitis in mice. Journal of Immunology 182, 6517-6526.
Acevedo, N., Mercado, D., Vergara, C., Sanchez, J., Kennedy, M. W., Jimenez, S., Fernandez, A. M., Gutierrez, M., Puerta, L. & Caraballo, L. (2009). Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes. Clinical and Experimental Immunology 157, 282-290.
Achatz-Straussberger, G., Zaborsky, N., Konigsberger, S., Feichtner, S., Lenz, S., Peckl-Schmid, D., Lamers, M. & Achatz, G. (2009). Limited humoral immunoglobulin E memory influences serum immunoglobulin E levels in blood. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 39, 1307-1313.
Aguado, E., Richelme, S., Nunez-Cruz, S., Miazek, A., Mura, A. M., Richelme, M., Guo, X. J., Sainty, D., He, H. T., Malissen, B. & Malissen, M. (2002). Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296, 2036-2040.
Akimoto, T., Numata, F., Tamura, M., Takata, Y., Higashida, N., Takashi, T., Takeda, K. & Akira, S. (1998). Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. The Journal of Experimental Medicine 187, 1537-1542.
Altmuller, J., Seidel, C., Lee, Y. A., Loesgen, S., Bulle, D., Friedrichs, F., Jellouschek, H., Kelber, J., Keller, A., Schuster, A., Silbermann, M., Wahlen, W., Wolff, P., Schlenvoigt, G., Ruschendorf, F., Nurnberg, P. & Wjst, M. (2005). Phenotypic and genetic heterogeneity in a genome-wide linkage study of asthma families. BMC Pulmonary Medicine 5, 1.
Anthoni, M., Wang, G., Deng, C., Wolff, H. J., Lauerma, A. I. & Alenius, H. T. (2007). Smad3 signal transducer regulates skin inflammation and specific IgE response in murine model of atopic dermatitis. The Journal of Investigative Dermatology 127, 1923-1929.
Arbesman, C. E., Wypych, J. I., Reisman, R. E. & Beutner, E. H. (1974). IgE levels in sera of patients with pemphigus or bullous pemphigoid. Archives of Dermatology 110, 378-381.
Badalová, J., Svobodová, M., Havelková, H., Vladimirov, V., Vojtíšková, J., Engová, J., Pilčík, T., Volf, P., Demant, P. & Lipoldová, M. (2002). Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Genes and Immunity 3, 187-195.
Bailey, D. W. (1971). Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11, 325-327.
Barbee, R. A., Halonen, M., Lebowitz, M. & Burrows, B. (1981). Distribution of IgE in a community population sample: correlations with age, sex, and allergen skin test reactivity. The Journal of Allergy and Clinical Immunology 68, 106-111.
Barton, D., HogenEsch, H. & Weih, F. (2000). Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis. European Journal of Immunology 30, 2323-2332.
Basehore, M. J., Howard, T. D., Lange, L. A., Moore, W. C., Hawkins, G. A., Marshik, P. L., Harkins, M. S., Meyers, D. A. & Bleecker, E. R. (2004). A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. The Journal of Allergy and Clinical Immunology 114, 80-87.
Beghe, B., Hall, I. P., Parker, S. G., Moffatt, M. F., Wardlaw, A., Connolly, M. J., Fabbri, L. M., Ruse, C. & Sayers, I. (2010). Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 65, 474-481.
Behnke, J. M., Iraqi, F. A., Mugambi, J. M., Clifford, S., Nagda, S., Wakelin, D., Kemp, S. J., Baker, R. L. & Gibson, J. P. (2006). High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice. Mammalian Genome 17, 584-597.
Ben-Sasson, S. Z., Hu-Li, J., Quiel, J., Cauchetaux, S., Ratner, M., Shapira, I., Dinarello, C. A. & Paul, W. E. (2009). IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proceedings of the National Academy of Sciences of the United States of America 106, 7119-7124.
Bevelander, M., Mayette, J., Whittaker, L. A., Paveglio, S. A., Jones, C. C., Robbins, J., Hemenway, D., Akira, S., Uematsu, S. & Poynter, M. E. (2007). Nitrogen dioxide promotes allergic sensitization to inhaled antigen. Journal of Immunology 179, 3680-3688.
Branda, C. S. & Dymecki, S. M. (2004). Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice. Developmental Cell 6, 7-28.
Brummer, E., Hanson, L. H. & Stevens, D. A. (1993). IL-4, IgE, and interferon-gamma production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (SCH 39304). Cellular Immunology 149, 258-267.
Burton, O. T. & Oettgen, H. C. (2011). Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunological Reviews 242, 128-143.
Cai, W. W., Chow, C. W., Damani, S., Gregory, S. G., Marra, M. & Bradley, A. (2001). An SSLP marker-anchored BAC framework map of the mouse genome. Nature Genetics 29, 133-134.
Carlborg, O. & Haley, C. S. (2004). Epistasis: too often neglected in complex trait studies? Nature Reviews Genetics 5, 618-625.
Carpenter, D., Abushama, H., Bereczky, S., Farnert, A., Rooth, I., Troye-Blomberg, M., Quinnell, R. J. & Shaw, M. A. (2007). Immunogenetic control of antibody responsiveness in a malaria endemic area. Human Immunology 68, 165-169.
Cassani, B., Poliani, P. L., Marrella, V., Schena, F., Sauer, A. V., Ravanini, M., Strina, D., Busse, C. E., Regenass, S., Wardemann, H., Martini, A., Facchetti, F., van der Burg, M., Rolink, A. G., Vezzoni, P., Grassi, F., Traggiai, E. & Villa, A. (2010). Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome. The Journal of Experimental Medicine 207, 1525-1540.
Castigli, E., Alt, F. W., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A. K. & Geha, R. S. (1994). CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proceedings of the National Academy of Sciences of the United States of America 91, 12135-12139.
Chan, A. C., Iwashima, M., Turck, C. W. & Weiss, A. (1992). ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71, 649-662.
Chavanas, S., Bodemer, C., Rochat, A., Hamel-Teillac, D., Ali, M., Irvine, A. D., Bonafe, J. L., Wilkinson, J., Taieb, A., Barrandon, Y., Harper, J. I., de Prost, Y. & Hovnanian, A. (2000). Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nature Genetics 25, 141-142.
Chehimi, J. & Trinchieri, G. (1994). Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. Journal of Clinical Immunology 14, 149-161.
Chong, K. K., Chiang, S. W., Wong, G. W., Tam, P. O., Ng, T. K., Hu, Y. J., Yam, G. H., Lam, D. S. & Pang, C. P. (2008). Association of CTLA-4 and IL-13 gene polymorphisms with Graves' disease and ophthalmopathy in Chinese children. Investigative Ophthalmology and Visual Science 49, 2409-2415.
Coffman, R. L. & Carty, J. (1986). A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. Journal of Immunology 136, 949-954.
Copeland, N. G., Jenkins, N. A. & Court, D. L. (2001). Recombineering: a powerful new tool for mouse functional genomics. Nature Reviews. Genetics 2, 769-779.
Corteling, R. & Trifilieff, A. (2004). Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment. BMC Pharmacology 4, 4.
CSGA (1997). The Collaborative Study on the Genetics of Asthma. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nature Genetics 15, 389-392.
Daniels, S. E., Bhattacharrya, S., James, A., Leaves, N. I., Young, A., Hill, M. R., Faux, J. A., Ryan, G. F., le Souef, P. N., Lathrop, G. M., Musk, A. W. & Cookson, W. O. (1996). A genome-wide search for quantitative trait loci underlying asthma. Nature 383, 247-250.
Darvasi, A. (1998). Experimental strategies for the genetic dissection of complex traits in animal models. Nature Genetics 18, 19-24.
Darvasi, A. & Soller, M. (1995). Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141, 1199-1207.
De Becker, G., Sornasse, T., Nabavi, N., Bazin, H., Tielemans, F., Urbain, J., Leo, O. & Moser, M. (1994). Immunoglobulin isotype regulation by antigen-presenting cells in vivo. European Journal of Immunology 24, 1523-1528.
DeBry, R. W. & Seldin, M. F. (1996). Human/mouse homology relationships. Genomics 33, 337-351.
Demant, P. & Hart, A. A. (1986). Recombinant congenic strains--a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 24, 416-422.
Derry, J. M., Ochs, H. D. & Francke, U. (1994). Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell 78, 635-644.
Dizier, M. H., Besse-Schmittler, C., Guilloud-Bataille, M., Annesi-Maesano, I., Boussaha, M., Bousquet, J., Charpin, D., Degioanni, A., Gormand, F., Grimfeld, A., Hochez, J., Hyne, G., Lockhart, A., Luillier-Lacombe, M., Matran, R., Meunier, F., Neukirch, F., Pacheco, Y., Parent, V., Paty, E., Pin, I., Pison, C., Scheinmann, P., Thobie, N., Vervloet, D., Kauffmann, F., Feingold, J., Lathrop, M. & Demenais, F. (2000). Genome screen for asthma and related phenotypes in the French EGEA study. American Journal of Respiratory and Critical Care Medicine 162, 1812-1818.
Dizier, M. H., James, A., Faux, J., Moffatt, M. F., Musk, A. W., Cookson, W. & Demenais, F. (1999). Segregation analysis of the specific response to allergens: a recessive major gene controls the specific IgE response to Timothy grass pollen. Genetic Epidemiology 16, 305-315.
Doi, T., Obayashi, K., Kadowaki, T., Fujii, H. & Koyasu, S. (2008). PI3K is a negative regulator of IgE production. International Immunology 20, 499-508.
Dokmeci, E., Xu, L., Robinson, E., Golubets, K., Bottomly, K. & Herrick, C. A. (2011). EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation. Immunology 132, 559-566.
Donfack, J., Schneider, D. H., Tan, Z., Kurz, T., Dubchak, I., Frazer, K. A. & Ober, C. (2005). Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy. Respiratory Research 6, 145.
Donovan, C. E., Mark, D. A., He, H. Z., Liou, H. C., Kobzik, L., Wang, Y., De Sanctis, G. T., Perkins, D. L. & Finn, P. W. (1999). NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. Journal of Immunology 163, 6827-6833.
Doutrelepont, J. M., Moser, M., Leo, O., Abramowicz, D., Vanderhaegen, M. L., Urbain, J. & Goldman, M. (1991). Hyper IgE in stimulatory graft-versus-host disease: role of interleukin-4. Clinical and Experimental Immunology 83, 133-136.
Driscoll, D. A., Budarf, M. L. & Emanuel, B. S. (1992). A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11. American Journal of Human Genetics 50, 924-933.
Duroudier, N. P., Strachan, D. P., Blakey, J. D. & Hall, I. P. (2009). Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort. The Journal of Allergy and Clinical Immunology 124, 566-572, 572.e1-3.
Ege, M., Ma, Y., Manfras, B., Kalwak, K., Lu, H., Lieber, M. R., Schwarz, K. & Pannicke, U. (2005). Omenn syndrome due to ARTEMIS mutations. Blood 105, 4179-4186.
Engelhardt, K. R., McGhee, S., Winkler, S., Sassi, A., Woellner, C., Lopez-Herrera, G., Chen, A., Kim, H. S., Lloret, M. G., Schulze, I., Ehl, S., Thiel, J., Pfeifer, D., Veelken, H., Niehues, T., Siepermann, K., Weinspach, S., Reisli, I., Keles, S., Genel, F., Kutukculer, N., Camcioglu, Y., Somer, A., Karakoc-Aydiner, E., Barlan, I., Gennery, A., Metin, A., Degerliyurt, A., Pietrogrande, M. C., Yeganeh, M., Baz, Z., Al-Tamemi, S., Klein, C., Puck, J. M., Holland, S. M., McCabe, E. R., Grimbacher, B. & Chatila, T. A. (2009). Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. The Journal of Allergy and Clinical Immunology 124, 1289-1302.
Erazo, A., Kutchukhidze, N., Leung, M., Christ, A. P., Urban, J. F. Jr., Curotto de Lafaille, M. A. & Lafaille, J. J. (2007). Unique maturation program of the IgE response in vivo. Immunity 26, 191-203.
Erwin, E. A., Ronmark, E., Wickens, K., Perzanowski, M. S., Barry, D., Lundback, B., Crane, J. & Platts-Mills, T. A. (2007). Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence. The Journal of Allergy and Clinical Immunology 119, 359-365.
Felices, M., Yin, C. C., Kosaka, Y., Kang, J. & Berg, L. J. (2009). Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo. Proceedings of the National Academy of Sciences of the United States of America 106, 8308-8313.
Ferreira, M. A., O'Gorman, L., Le Souef, P., Burton, P. R., Toelle, B. G., Robertson, C. F., Visscher, P. M., Martin, N. G. & Duffy, D. L. (2005). Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13. American Journal of Human Genetics 77, 1075-1085.
Fonseca, B. P., Olsen, P. C., Coelho, L. P., Ferreira, T. P., Souza, H. S., Martins, M. A. & Viola, J. P. (2009). NFAT1 transcription factor regulates pulmonary allergic inflammation and airway responsiveness. American Journal of Respiratory Cell and Molecular Biology 40, 66-75.
Frankel, W. N. & Schork, N. J. (1996). Who's afraid of epistasis? Nature Genetics 14, 371-373.
Freeman, A. F., Avila, E. M., Shaw, P. A., Davis, J., Hsu, A. P., Welch, P., Matta, J. R., Hadigan, C., Pettigrew, R. I., Holland, S. M. & Gharib, A. M. (2011). Coronary artery abnormalities in Hyper-IgE syndrome. Journal of Clinical Immunology 31, 338-345.
Galli, S. J. & Tsai, M. (2012). IgE and mast cells in allergic disease. Nature Medicine 18, 693-704.
Giblin, W., Chatterji, M., Westfield, G., Masud, T., Theisen, B., Cheng, H. L., DeVido, J., Alt, F. W., Ferguson, D. O., Schatz, D. G. & Sekiguchi, J. (2009). Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood 113, 2965-2975.
Giliani, S., Bonfim, C., de Saint Basile, G., Lanzi, G., Brousse, N., Koliski, A., Malvezzi, M., Fischer, A., Notarangelo, L. D. & Le Deist, F. (2006). Omenn syndrome in an infant with IL7RA gene mutation. The Journal of Pediatrics 148, 272-274.
Gordon, E. D., Sidhu, S. S., Wang, Z. E., Woodruff, P. G., Yuan, S., Solon, M. C., Conway, S. J., Huang, X., Locksley, R. M. & Fahy, J. V. (2012). A protective role for periostin and TGF-beta in IgE-mediated allergy and airway hyperresponsiveness. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 42, 144-155.
Gould, H. J. & Sutton, B. J. (2008). IgE in allergy and asthma today. Nature Reviews. Immunology 8, 205-217.
Granada, M., Wilk, J. B., Tuzova, M., Strachan, D. P., Weidinger, S., Albrecht, E., Gieger, C., Heinrich, J., Himes, B. E., Hunninghake, G. M., Celedon, J. C., Weiss, S. T., Cruikshank, W. W., Farrer, L. A., Center, D. M. & O'Connor, G. T. (2012). A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. The Journal of Allergy and Clinical Immunology 129, 840-845.
Grant, A. V., Araujo, M. I., Ponte, E. V., Oliveira, R. R., Cruz, A. A., Barnes, K. C. & Beaty, T. H. (2008). High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population. Journal of Infectious Diseases 198, 1227-1236.
Graves, P. E., Kabesch, M., Halonen, M., Holberg, C. J., Baldini, M., Fritzsch, C., Weiland, S. K., Erickson, R. P., von Mutius, E. & Martinez, F. D. (2000). A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. The Journal of Allergy and Clinical Immunology 105, 506-513.
Grigoreas, C., Pappas, D., Galatas, I. D., Kollias, G., Papadimos, S. & Papadakis, P. (1993). Serum total IgE levels in a representative sample of a Greek population. I. Correlation with age, sex, and skin reactivity to common aeroallergens. Allergy 48, 142-146.
Gruber, T. A., Shah, A. J., Hernandez, M., Crooks, G. M., Abdel-Azim, H., Gupta, S., McKnight, S., White, D., Kapoor, N. & Kohn, D. B. (2009). Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency. Pediatric Transplantation 13, 244-250.
Grunebaum, E., Bates, A. & Roifman, C. M. (2008). Omenn syndrome is associated with mutations in DNA ligase IV. The Journal of Allergy and Clinical Immunology 122, 1219-1220.
Grzmil, P., Konietzko, J., Boehm, D., Holter, S. M., Aguilar-Pimentel, A., Javaheri, A., Kalaydjiev, S., Adler, T., Bolle, I., Adham, I., Dixkens, C., Wolf, S., Fuchs, H., Gailus-Durner, V., Wurst, W., Ollert, M., Busch, D. H., Schulz, H., de Angelis, M. H. & Burfeind, P. (2009). Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. Cytogenetic and Genome Research 125, 186-200.
Guo, X. J., Li, J., Ni, P. H., Ren, L. P. & Xu, W. G. (2008). The transcription levels of linker for activation of T cell and its upstream regulatory factors in T cells of asthmatic patients. Zhonghua Jie He He Hu Xi Za Zhi 31, 125-128.
Gusareva, E. S., Havelková, H., Blažková, H., Kosařová, M., Kučera, P., Král, V., Salyakina, D., Müller-Myhsok, B. & Lipoldová, M. (2009). Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12. Immunogenetics 61, 15-25.
Gusareva, E. S., Ogorodova, L. M., Chernyak, B. A. & Lipoldová, M. (2008). Relationship between total and specific IgE in patients with asthma from Siberia. The Journal of Allergy and Clinical Immunology 121, 781; author reply 781.
Haagerup, A., Bjerke, T., Schiotz, P. O., Binderup, H. G., Dahl, R. & Kruse, T. A. (2002). Asthma and atopy-a total genome scan for susceptibility genes. Allergy 57, 680-686.
Haczku, A., Takeda, K., Hamelmann, E., Oshiba, A., Loader, J., Joetham, A., Irvin, C., Kikutani, H. & Gelfand, E. W. (1997). CD23 deficient mice develop allergic airway hyperresponsiveness following sensitization with ovalbumin. American Journal of Respiratory and Critical Care Medicine 156, 1945-1955.
Hajek, A. R., Lindley, A. R., Favoreto, S. Jr., Carter, R., Schleimer, R. P. & Kuperman, D. A. (2008). 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. The Journal of Allergy and Clinical Immunology 122, 633-639.e3.
Hattori, H., Rosas, L. E., Okano, M., Durbin, J. E., Nishizaki, K. & Satoskar, A. R. (2007). STAT1 is involved in the pathogenesis of murine allergic rhinitis. American Journal of Rhinology 21, 241-247.
Havelková, H., Badalová, J., Svobodová, M., Vojtíšková, J., Kurey, I., Vladimirov, V., Demant, P. & Lipoldová, M. (2006). Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes and Immunity 7, 220-233.
Heyd, J., Donnenberg, A. D., Burns, W. H., Saral, R. & Santos, G. W. (1988). Immunoglobulin E levels following allogeneic, autologous, and syngeneic bone marrow transplantation: an indirect association between hyperproduction and acute graft-v-host disease in allogeneic BMT. Blood 72, 442-446.
Hikita, I., Yoshioka, T., Mizoguchi, T., Tsukahara, K., Tsuru, K., Nagai, H., Hirasawa, T., Tsuruta, Y., Suzuki, R., Ichihashi, M. & Horikawa, T. (2002). Characterization of dermatitis arising spontaneously in DS-Nh mice maintained under conventional conditions: another possible model for atopic dermatitis. Journal of Dermatological Science 30, 142-153.
Hivroz, C. (2005). Everything you ever wanted to know about ZAP-70. Médecine Sciences (Paris) 21, 150-155.
Holla, L. I., Schuller, M., Buckova, D. & Vacha, J. (2004). Neuronal nitric oxide synthase gene polymorphism and IgE-mediated allergy in the Central European population. Allergy 59, 548-552.
Holland, S. M., DeLeo, F. R., Elloumi, H. Z., Hsu, A. P., Uzel, G., Brodsky, N., Freeman, A. F., Demidowich, A., Davis, J., Turner, M. L., Anderson, V. L., Darnell, D. N., Welch, P. A., Kuhns, D. B., Frucht, D. M., Malech, H. L., Gallin, J. I., Kobayashi, S. D., Whitney, A. R., Voyich, J. M., Musser, J. M., Woellner, C., Schaffer, A. A., Puck, J. M. & Grimbacher, B. (2007). STAT3 mutations in the hyper-IgE syndrome. The New England Journal of Medicine 357, 1608-1619.
Howard, T. D., Postma, D. S., Hawkins, G. A., Koppelman, G. H., Zheng, S. L., Wysong, A. K., Xu, J., Meyers, D. A. & Bleecker, E. R. (2002). Fine mapping of an IgE-controlling gene on chromosome 2q: analysis of CTLA4 and CD28. The Journal of Allergy and Clinical Immunology 110, 743-751.
Huerta-Yepez, S., Baay-Guzman, G. J., Bebenek, I. G., Hernandez-Pando, R., Vega, M. I., Chi, L., Riedl, M., Diaz-Sanchez, D., Kleerup, E., Tashkin, D. P., Gonzalez, F. J., Bonavida, B., Zeidler, M. & Hankinson, O. (2011). Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. Allergy 66, 909-918.
Hunninghake, G. M., Lasky-Su, J., Soto-Quiros, M. E., Avila, L., Liang, C., Lake, S. L., Hudson, T. J., Spesny, M., Fournier, E., Sylvia, J. S., Freimer, N. B., Klanderman, B. J., Raby, B. A. & Celedon, J. C. (2008). Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. American Journal of Respiratory and Critical Care Medicine 177, 830-836.
Imboden, M., Nieters, A., Bircher, A. J., Brutsche, M., Becker, N., Wjst, M., Ackermann-Liebrich, U., Berger, W. & Probst-Hensch, N. M. (2006). Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). Clinical and Molecular Allergy: CMA 4, 9.
Immervoll, T., Loesgen, S., Dutsch, G., Gohlke, H., Herbon, N., Klugbauer, S., Dempfle, A., Bickeboller, H., Becker-Follmann, J., Ruschendorf, F., Saar, K., Reis, A., Wichmann, H. E. & Wjst, M. (2001). Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Human Mutation 18, 327-336.
Ioannou, P. A., Amemiya, C. T., Garnes, J., Kroisel, P. M., Shizuya, H., Chen, C., Batzer, M. A. & de Jong, P. J. (1994). A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nature Genetics 6, 84-89.
Ishiura, N., Fujimoto, M., Watanabe, R., Nakashima, H., Kuwano, Y., Yazawa, N., Echigo, T., Okochi, H. & Tamaki, K. (2008). Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid. Journal of Dermatological Science 49, 153-161.
Ishiwata, K., Watanabe, N., Guo, M., Tomihara, K., Brumlik, M. J., Yagita, H., Pardoll, D., Chen, L. & Shin, T. (2010). Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. Journal of Immunology 184, 2086-2094.
Iyer, A. S., Morales, J. L., Huang, W., Ojo, F., Ning, G., Wills, E., Baines, J. D. & August, A. (2011). Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses. The Journal of Biological Chemistry 286, 9503-9513.
Jabara, H. H., McDonald, D. R., Janssen, E., Massaad, M. J., Ramesh, N., Borzutzky, A., Rauter, I., Benson, H., Schneider, L., Baxi, S., Recher, M., Notarangelo, L. D., Wakim, R., Dbaibo, G., Dasouki, M., Al-Herz, W., Barlan, I., Baris, S., Kutukculer, N., Ochs, H. D., Plebani, A., Kanariou, M., Lefranc, G., Reisli, I., Fitzgerald, K. A., Golenbock, D., Manis, J., Keles, S., Ceja, R., Chatila, T. A. & Geha, R. S. (2012). DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nature Immunology 13, 612-620.
Jabara, H. H. & Vercelli, D. (1994). Engagement of CD14 on monocytes inhibits the synthesis of human Igs, including IgE. Journal of Immunology 153, 972-978.
Jacobsen, H. P., Herskind, A. M., Nielsen, B. W. & Husby, S. (2001). IgE in unselected like-sexed monozygotic and dizygotic twins at birth and at 6-9years of age: high but dissimilar genetic influence on IgE levels. The Journal of Allergy and Clinical Immunology 107, 659-663.
Jakob, T., Kollisch, G. V., Howaldt, M., Bewersdorff, M., Rathkolb, B., Muller, M. L., Sandholzer, N., Nitschke, L., Schiemann, M., Mempel, M., Ollert, M., Neubauer, A., Soewarto, D. A., Kremmer, E., Ring, J., Behrendt, H. & Flaswinkel, H. (2008). Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. The Journal of Allergy and Clinical Immunology 121, 179-184.e7.
Johnson, C. C., Peterson, E. L. & Ownby, D. R. (1998). Gender differences in total and allergen-specific immunoglobulin E (IgE) concentrations in a population-based cohort from birth to age four years. American Journal of Epidemiology 147, 1145-1152.
Kabesch, M., Schedel, M., Carr, D., Woitsch, B., Fritzsch, C., Weiland, S. K. & von Mutius, E. (2006). IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. The Journal of Allergy and Clinical Immunology 117, 269-274.
Kadkhoda, K., Wang, S., Fan, Y., Qiu, H., Basu, S., Halayko, A. J. & Yang, X. (2011). ICOS ligand expression is essential for allergic airway hyperresponsiveness. International Immunology 23, 239-249.
Kaplan, B. L., Lawver, J. E., Karmaus, P. W., Ngaotepprutaram, T., Birmingham, N. P., Harkema, J. R. & Kaminski, N. E. (2010). The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin. Toxicologic Pathology 38, 382-392.
Karagiannis, S. N., Bracher, M. G., Hunt, J., McCloskey, N., Beavil, R. L., Beavil, A. J., Fear, D. J., Thompson, R. G., East, N., Burke, F., Moore, R. J., Dombrowicz, D. D., Balkwill, F. R. & Gould, H. J. (2007). IgE-antibody-dependent immunotherapy of solid tumors: cytotoxic and phagocytic mechanisms of eradication of ovarian cancer cells. Journal of Immunology 179, 2832-2843.
Karjalainen, J., Hulkkonen, J., Nieminen, M. M., Huhtala, H., Aromaa, A., Klaukka, T. & Hurme, M. (2003). Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 33, 78-83.
Kasprowicz, D. J., Kohm, A. P., Berton, M. T., Chruscinski, A. J., Sharpe, A. & Sanders, V. M. (2000). Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell. Journal of Immunology 165, 680-690.
Kawakami, M., Narumoto, O., Matsuo, Y., Horiguchi, K., Horiguchi, S., Yamashita, N., Sakaguchi, M., Lipp, M. & Nagase, T. (2012). The role of CCR7 in allergic airway inflammation induced by house dust mite exposure. Cellular Immunology 275, 24-32.
Kerkhof, M., Droste, J. H., de Monchy, J. G., Schouten, J. P. & Rijcken, B. (1996). Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20-70years. Dutch ECRHS Group, European Community Respiratory Health Study. Allergy 51, 770-776.
Khiong, K., Murakami, M., Kitabayashi, C., Ueda, N., Sawa, S., Sakamoto, A., Kotzin, B. L., Rozzo, S. J., Ishihara, K., Verella-Garcia, M., Kappler, J., Marrack, P. & Hirano, T. (2007). Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. The Journal of Clinical Investigation 117, 1270-1281.
Kim, D. Y., Fukuyama, S., Nagatake, T., Takamura, K., Kong, I. G., Yokota, Y., Lee, C. H. & Kiyono, H. (2012). Implications of nasopharynx-associated lymphoid tissue (NALT) in the development of allergic responses in an allergic rhinitis mouse model. Allergy 67, 502-509.
Knisz, J., Banks, A., McKeag, L., Metcalfe, D. D., Rothman, P. B. & Brown, J. M. (2009). Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation. Clinical Immunology 132, 277-284.
Koltsida, O., Hausding, M., Stavropoulos, A., Koch, S., Tzelepis, G., Ubel, C., Kotenko, S. V., Sideras, P., Lehr, H. A., Tepe, M., Klucher, K. M., Doyle, S. E., Neurath, M. F., Finotto, S. & Andreakos, E. (2011). IL-28A (IFN-lambda2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease. EMBO Molecular Medicine 3, 348-361.
Koppelman, G. H., Stine, O. C., Xu, J., Howard, T. D., Zheng, S. L., Kauffman, H. F., Bleecker, E. R., Meyers, D. A. & Postma, D. S. (2002). Genome-wide search for atopy susceptibility genes in Dutch families with asthma. The Journal of Allergy and Clinical Immunology 109, 498-506.
Kuperman, D., Schofield, B., Wills-Karp, M. & Grusby, M. J. (1998). Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. The Journal of Experimental Medicine 187, 939-948.
Kurey, I., Kobets, T., Havelková, H., Slapničková, M., Quan, L., Trtková, K., Grekov, I., Svobodová, M., Stassen, A. P., Hutson, A., Demant, P. & Lipoldová, M. (2009). Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics 61, 619-633.
Kuroda, E., Antignano, F., Ho, V. W., Hughes, M. R., Ruschmann, J., Lam, V., Kawakami, T., Kerr, W. G., McNagny, K. M., Sly, L. M. & Krystal, G. (2011). SHIP represses Th2 skewing by inhibiting IL-4 production from basophils. Journal of Immunology 186, 323-332.
Kurokawa, M., Konno, S., Takahashi, A., Plunkett, B., Rittling, S. R., Matsui, Y., Kon, S., Morimoto, J., Uede, T., Matsukura, S., Kokubu, F., Adachi, M., Nishimura, M. & Huang, S. K. (2009). Regulatory role of DC-derived osteopontin in systemic allergen sensitization. European Journal of Immunology 39, 3323-3330.
Kurz, T., Altmueller, J., Strauch, K., Ruschendorf, F., Heinzmann, A., Moffatt, M. F., Cookson, W. O., Inacio, F., Nurnberg, P., Stassen, H. H. & Deichmann, K. A. (2005). A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3. Allergy 60, 192-199.
Laitinen, T., Daly, M. J., Rioux, J. D., Kauppi, P., Laprise, C., Petays, T., Green, T., Cargill, M., Haahtela, T., Lander, E. S., Laitinen, L. A., Hudson, T. J. & Kere, J. (2001). A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nature Genetics 28, 87-91.
Laitinen, T., Polvi, A., Rydman, P., Vendelin, J., Pulkkinen, V., Salmikangas, P., Makela, S., Rehn, M., Pirskanen, A., Rautanen, A., Zucchelli, M., Gullsten, H., Leino, M., Alenius, H., Petays, T., Haahtela, T., Laitinen, A., Laprise, C., Hudson, T. J., Laitinen, L. A. & Kere, J. (2004). Characterization of a common susceptibility locus for asthma-related traits. Science 304, 300-304.
Lander, E. S. & Schork, N. J. (1994). Genetic dissection of complex traits. Science 265, 2037-2048.
Laouini, D., Elkhal, A., Yalcindag, A., Kawamoto, S., Oettgen, H. & Geha, R. S. (2005). COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. The Journal of Allergy and Clinical Immunology 116, 390-396.
Lee, J. H., Kim, K. W., Gee, H. Y., Lee, J., Lee, K. H., Park, H. S., Kim, S. H., Kim, S. W., Kim, M. N., Kim, K. E., Kim, K. H., Lee, M. G. & Sohn, M. H. (2011). A synonymous variation in protease-activated receptor-2 is associated with atopy in Korean children. The Journal of Allergy and Clinical Immunology 128, 1326-1334.
Lee, C., Kolesnik, T. B., Caminschi, I., Chakravorty, A., Carter, W., Alexander, W. S., Jones, J., Anderson, G. P. & Nicholson, S. E. (2009a). Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 39, 897-907.
Lee, J. Y., Park, A. K., Lee, K. M., Park, S. K., Han, S., Han, W., Noh, D. Y., Yoo, K. Y., Kim, H., Chanock, S. J., Rothman, N. & Kang, D. (2009b). Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. Carcinogenesis 30, 1528-1531.
Leung, T. F., Liu, E. K., Tang, N. L., Ko, F. W., Li, C. Y., Lam, C. W. & Wong, G. W. (2005). Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 35, 1288-1294.
Lewis, G., Rapsomaniki, E., Bouriez, T., Crockford, T., Ferry, H., Rigby, R., Vyse, T., Lambe, T. & Cornall, R. (2004). Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. Immunogenetics 56, 564-571.
Li, Y., Sun, M., Cheng, H., Li, S., Liu, L., Qiao, H., Hua, S. & Lu, J. (2011). Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice. Experimental & Molecular Medicine 43, 197-204.
Liang, H. E., Reinhardt, R. L., Bando, J. K., Sullivan, B. M., Ho, I. C. & Locksley, R. M. (2012). Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nature Immunology 13, 58-66.
Lin, J. X., Migone, T. S., Tsang, M., Friedmann, M., Weatherbee, J. A., Zhou, L., Yamauchi, A., Bloom, E. T., Mietz, J., John, S., et al. (1995). The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2, 331-339.
Lipoldová, M. & Demant, P. (2006). Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nature Reviews. Genetics 7, 294-305.
Lipoldová, M., Londei, M., Grubeck-Loebenstein, B., Feldmann, M. & Owen, M. J. (1989). Analysis of T-cell receptor usage in activated T-cell clones from Hashimoto's thyroiditis and Graves' disease. Journal of Autoimmunity 2, 1-13.
Lipoldová, M., Svobodová, M., Havelková, H., Krulová, M., Badalová, J., Nohýnková, E., Hart, A. A., Schlegel, D., Volf, P. & Demant, P. (2002). Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis. Immunogenetics 54, 174-183.
Lipoldová, M., Svobodová, M., Krulová, M., Havelková, H., Badalová, J., Nohýnková, E., Holáň, V., Hart, A. A., Volf, P. & Demant, P. (2000). Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Genes and Immunity 1, 200-206.
Liu, X., Beaty, T. H., Deindl, P., Huang, S. K., Lau, S., Sommerfeld, C., Fallin, M. D., Kao, W. H., Wahn, U. & Nickel, R. (2004). Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. The Journal of Allergy and Clinical Immunology 113, 489-495.
Lucey, D. R., Clerici, M. & Shearer, G. M. (1996). Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clinical Microbiology Reviews 9, 532-562.
Lynch, N. R., Yarzabal, L., Verde, O., Avila, J. L., Monzon, H. & Convit, J. (1982). Delayed-type hypersensitivity and immunoglobulin E in American cutaneous leishmaniasis. Infection and Immunity 38, 877-881.
Maggi, E., Del Prete, G. F., Parronchi, P., Tiri, A., Macchia, D., Biswas, P., Simonelli, C., Ricci, M. & Romagnani, S. (1989). Role for T cells, IL-2 and IL-6 in the IL-4-dependent in vitro human IgE synthesis. Immunology 68, 300-306.
Maier, L. M., Howson, J. M., Walker, N., Spickett, G. P., Jones, R. W., Ring, S. M., McArdle, W. L., Lowe, C. E., Bailey, R., Payne, F., Todd, J. A. & Strachan, D. P. (2006). Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. The Journal of Allergy and Clinical Immunology 117, 1306-1313.
Maillet, I., Schnyder-Candrian, S., Couillin, I., Quesniaux, V. F., Erard, F., Moser, R., Fleury, S., Kanda, A., Dombrowicz, D., Szymkowski, D. E. & Ryffel, B. (2011). Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics. American Journal of Respiratory Cell and Molecular Biology 45, 731-739.
Maizels, R. M., Pearce, E. J., Artis, D., Yazdanbakhsh, M. & Wynn, T. A. (2009). Regulation of pathogenesis and immunity in helminth infections. The Journal of Experimental Medicine 206, 2059-2066.
Marino, R., Thuraisingam, T., Camateros, P., Kanagaratham, C., Xu, Y. Z., Henri, J., Yang, J., He, G., Ding, A. & Radzioch, D. (2011). Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice. Journal of Immunology 186, 4433-4442.
Mark, D. A., Donovan, C. E., De Sanctis, G. T., He, H. Z., Cernadas, M., Kobzik, L., Perkins, D. L., Sharpe, A. & Finn, P. W. (2000). B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology 22, 265-271.
Markel, P., Shu, P., Ebeling, C., Carlson, G. A., Nagle, D. L., Smutko, J. S. & Moore, K. J. (1997). Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nature Genetics 17, 280-284.
Marrella, V., Poliani, P. L., Casati, A., Rucci, F., Frascoli, L., Gougeon, M. L., Lemercier, B., Bosticardo, M., Ravanini, M., Battaglia, M., Roncarolo, M. G., Cavazzana-Calvo, M., Facchetti, F., Notarangelo, L. D., Vezzoni, P., Grassi, F. & Villa, A. (2007). A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome. The Journal of Clinical Investigation 117, 1260-1269.
Mathias, R. A., Beaty, T. H., Bailey-Wilson, J. E., Bickel, C., Stockton, M. L. & Barnes, K. C. (2005). Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses. Human Heredity 59, 228-238.
Mathur, M., Herrmann, K., Qin, Y., Gulmen, F., Li, X., Krimins, R., Weinstock, J., Elliott, D., Bluestone, J. A. & Padrid, P. (1999). CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice. American Journal of Respiratory Cell and Molecular Biology 21, 498-509.
Matta, G. M., Battaglio, S., Dibello, C., Napoli, P., Baldi, C., Ciccone, G., Coscia, M., Boccadoro, M. & Massaia, M. (2007). Polyclonal immunoglobulin E levels are correlated with hemoglobin values and overall survival in patients with multiple myeloma. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 13, 5348-5354.
Matthews, A. G. & Oettinger, M. A. (2009). RAG: a recombinase diversified. Nature Immunology 10, 817-821.
McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T. & DeKruyff, R. H. (2001). Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature Immunology 2, 1109-1116.
McLane, M. P., Haczku, A., van de Rijn, M., Weiss, C., Ferrante, V., MacDonald, D., Renauld, J. C., Nicolaides, N. C., Holroyd, K. J. & Levitt, R. C. (1998). Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. American Journal of Respiratory Cell and Molecular Biology 19, 713-720.
McVean, G., Spencer, C. C. & Chaix, R. (2005). Perspectives on human genetic variation from the HapMap Project. PLoS Genetics 1, e54.
Melgert, B. N., Postma, D. S., Kuipers, I., Geerlings, M., Luinge, M. A., van der Strate, B. W., Kerstjens, H. A., Timens, W. & Hylkema, M. N. (2005). Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 35, 1496-1503.
Meller, N., Merlot, S. & Guda, C. (2005). CZH proteins: a new family of Rho-GEFs. Journal of Cell Science 118, 4937-4946.
Menge, D. M., Behnke, J. M., Lowe, A., Gibson, J. P., Iraqi, F. A., Baker, R. L. & Wakelin, D. (2003). Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice. Parasite Immunology 25, 341-349.
Michel, T., Thérésine, M., Poli, A., Domingues, O., Ammerlaan, W., Brons, N. H., Hentges, F. & Zimmer, J. (2011). Increased Th2 cytokine secretion, eosinophilic airway inflammation, and airway hyperresponsiveness in neurturin-deficient mice. Journal of Immunology 186, 6497-6504.
Minegishi, Y. (2009). Hyper-IgE syndrome. Current Opinion in Immunology 21, 487-492.
Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, I., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H. D., Renner, E. D., Jansson, A., Belohradsky, B. H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S. & Karasuyama, H. (2006). Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25, 745-755.
Minegishi, Y., Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., Yamada, M., Kawamura, N., Ariga, T., Tsuge, I. & Karasuyama, H. (2009). Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. The Journal of Experimental Medicine 206, 1291-1301.
Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara, T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A. & Karasuyama, H. (2007). Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448, 1058-1062.
Mitsuyasu, H., Yanagihara, Y., Mao, X. Q., Gao, P. S., Arinobu, Y., Ihara, K., Takabayashi, A., Hara, T., Enomoto, T., Sasaki, S., Kawai, M., Hamasaki, N., Shirakawa, T., Hopkin, J. M. & Izuhara, K. (1999). Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis. Journal of Immunology 162, 1227-1231.
Mobini, R., Andersson, B. A., Erjefalt, J., Hahn-Zoric, M., Langston, M. A., Perkins, A. D., Cardell, L. O. & Benson, M. (2009). A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation. BMC Systems Biology 3, 19.
Moffatt, M. F., Gut, I. G., Demenais, F., Strachan, D. P., Bouzigon, E., Heath, S., von Mutius, E., Farrall, M., Lathrop, M. & Cookson, W. O. (2010). A large-scale, consortium-based genomewide association study of asthma. The New England Journal of Medicine 363, 1211-1221.
Moller, M., Gravenor, M. B., Roberts, S. E., Sun, D., Gao, P. & Hopkin, J. M. (2007). Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms. Human Molecular Genetics 16, 1828-1836.
Mori, T., Saito, K., Ohki, Y., Arakawa, H., Tominaga, M. & Tokuyama, K. (2011). Lack of transient receptor potential vanilloid-1 enhances Th2-biased immune response of the airways in mice receiving intranasal, but not intraperitoneal, sensitization. International Archives of Allergy and Immunology 156, 305-312.
Morita, H., Arae, K., Ohno, T., Kajiwara, N., Oboki, K., Matsuda, A., Suto, H., Okumura, K., Sudo, K., Takahashi, T., Matsumoto, K. & Nakae, S. (2012). ST2 requires Th2-, but not Th17- type airway inflammation in epicutaneously antigen-sensitized mice. Allergology International: Official Journal of the Japanese Society of Allergology 61, 265-273.
Mueller, C. & August, A. (2003). Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. Journal of Immunology 170, 5056-5063.
Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. & Honjo, T. (2000). Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563.
Nadeau, J. H., Singer, J. B., Matin, A. & Lander, E. S. (2000). Analysing complex genetic traits with chromosome substitution strains. Nature Genetics 24, 221-225.
Nagarkatti, R., Rao, C. B., Rishi, J. P., Chetiwal, R., Shandilya, V., Vijayan, V., Kumar, R., Pemde, H. K., Sharma, S. K., Sharma, S., Singh, A. B., Gangal, S. V. & Ghosh, B. (2002). Association of IFNG gene polymorphism with asthma in the Indian population. The Journal of Allergy and Clinical Immunology 110, 410-412.
Nakagawa, Y., Takamatsu, H., Okuno, T., Kang, S., Nojima, S., Kimura, T., Kataoka, T. R., Ikawa, M., Toyofuku, T., Katayama, I. & Kumanogoh, A. (2011). Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses. Journal of Immunology 186, 2881-2888.
Ng, F. S., Wong, K. Y., Guan, S. P., Mustafa, F. B., Kajiji, T. S., Bist, P., Biswas, S. K., Wong, W. S. & Lim, L. H. (2011). Annexin-1-deficient mice exhibit spontaneous airway hyperresponsiveness and exacerbated allergen-specific antibody responses in a mouse model of asthma. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 41, 1793-1803.
Nicolaides, N. C., Holroyd, K. J., Ewart, S. L., Eleff, S. M., Kiser, M. B., Dragwa, C. R., Sullivan, C. D., Grasso, L., Zhang, L. Y., Messler, C. J., Zhou, T., Kleeberger, S. R., Buetow, K. H. & Levitt, R. C. (1997). Interleukin 9: a candidate gene for asthma. Proceedings of the National Academy of Sciences of the United States of America 94, 13175-13180.
Noble, A., Leggat, J. A. & Inderberg, E. M. (2003). CD8+ immunoregulatory cells in the graft-versus-host reaction: CD8 T cells activate dendritic cells to secrete interleukin-12/interleukin-18 and induce T helper 1 autoantibody. Immunology 109, 476-486.
Nomiya, R., Okano, M., Fujiwara, T., Maeda, M., Kimura, Y., Kino, K., Yokoyama, M., Hirai, H., Nagata, K., Hara, T., Nishizaki, K. & Nakamura, M. (2008). CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. Journal of Immunology 180, 5680-5688.
Nunez-Cruz, S., Aguado, E., Richelme, S., Chetaille, B., Mura, A. M., Richelme, M., Pouyet, L., Jouvin-Marche, E., Xerri, L., Malissen, B. & Malissen, M. (2003). LAT regulates gammadelta T cell homeostasis and differentiation. Nature Immunology 4, 999-1008.
Ober, C., Tsalenko, A., Parry, R. & Cox, N. J. (2000). A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. American Journal of Human Genetics 67, 1154-1162.
Odom, S., Gomez, G., Kovarova, M., Furumoto, Y., Ryan, J. J., Wright, H. V., Gonzalez-Espinosa, C., Hibbs, M. L., Harder, K. W. & Rivera, J. (2004). Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. The Journal of Experimental Medicine 199, 1491-1502.
Ohmichi, Y., Hirakawa, J., Imai, Y., Fukuda, M. & Kawashima, H. (2011). Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. The Journal of Experimental Medicine 208, 1015-1025.
Ohwada, K., Watanabe, K., Okuyama, K., Ohkawara, Y., Sugaya, T., Takayanagi, M. & Ohno, I. (2007). The involvement of type 1a angiotensin II receptors in the regulation of airway inflammation in a murine model of allergic asthma. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 37, 1720-1727.
Ozaki, K., Spolski, R., Feng, C. G., Qi, C. F., Cheng, J., Sher, A., Morse, H. C. III, Liu, C., Schwartzberg, P. L. & Leonard, W. J. (2002). A critical role for IL-21 in regulating immunoglobulin production. Science 298, 1630-1634.
Ozcan, E., Notarangelo, L. D. & Geha, R. S. (2008). Primary immune deficiencies with aberrant IgE production. The Journal of Allergy and Clinical Immunology 122, 1054-1062; quiz 1063-1064.
Palmer, L. J., Cookson, W. O., James, A. L., Musk, A. W. & Burton, P. R. (2001). Gibbs sampling-based segregation analysis of asthma-associated quantitative traits in a population-based sample of nuclear families. Genetic Epidemiology 20, 356-372.
Park, M. K., Cho, M. K., Kang, S. A., Park, H. K., Kim, Y. S., Kim, K. U., Ahn, S. C., Kim, D. H. & Yu, H. S. (2011). Protease-activated receptor 2 is involved in Th2 responses against Trichinella spiralis infection. The Korean Journal of Parasitology 49, 235-243.
Park, J. W., Min, H. J., Sohn, J. H., Kim, J. Y., Hong, J. H., Sigrist, K. S., Glimcher, L. H. & Hwang, E. S. (2009). Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma. The Journal of Allergy and Clinical Immunology 123, 479-485.
Pattaro, C., Heinrich, J., Werner, M., de Marco, R. & Wjst, M. (2006). Association between interleukin-1 receptor antagonist gene and asthma-related traits in a German adult population. Allergy 61, 239-244.
Polte, T., Fuchs, L., Behrendt, A. K. & Hansen, G. (2009). Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model. European Journal of Immunology 39, 1736-1742.
Porcherie, A., Mathieu, C., Peronet, R., Schneider, E., Claver, J., Commere, P. H., Kiefer-Biasizzo, H., Karasuyama, H., Milon, G., Dy, M., Kinet, J. P., Louis, J., Blank, U. & Mecheri, S. (2011). Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. The Journal of Experimental Medicine 208, 2225-2236.
Postma, D. S., Bleecker, E. R., Amelung, P. J., Holroyd, K. J., Xu, J., Panhuysen, C. I., Meyers, D. A. & Levitt, R. C. (1995). Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. The New England Journal of Medicine 333, 894-900.
Prescott, S. & Saffery, R. (2012). The role of epigenetic dysregulation in the epidemic of allergic disease. Clinical Epigenetics 2, 223-232.
Qazi, M. R., Abedi, M. R., Nelson, B. D., Depierre, J. W. & Abedi-Valugerdi, M. (2011). Characterization of the hepatic and splenic immune status and immunoglobulin synthesis in aged male mice lacking the peroxisome proliferator-activated receptor-alpha (PPARalpha). Scandinavian Journal of Immunology 73, 198-207.
Quan, S. H., Zhang, Y. L., Han, D. H., Iwakura, Y. & Rhee, C. S. (2012). Contribution of interleukin 17A to the development and regulation of allergic inflammation in a murine allergic rhinitis model. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma & Immunology 108, 342-350.
Raby, B. A., Klanderman, B., Murphy, A., Mazza, S., Camargo, C. A. Jr., Silverman, E. K. & Weiss, S. T. (2007). A common mitochondrial haplogroup is associated with elevated total serum IgE levels. The Journal of Allergy and Clinical Immunology 120, 351-358.
Ramasamy, A., Curjuric, I., Coin, L. J., Kumar, A., McArdle, W. L., Imboden, M., Leynaert, B., Kogevinas, M., Schmid-Grendelmeier, P., Pekkanen, J., Wjst, M., Bircher, A. J., Sovio, U., Rochat, T., Hartikainen, A. L., Balding, D. J., Jarvelin, M. R., Probst-Hensch, N., Strachan, D. P. & Jarvis, D. L. (2011). A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. The Journal of Allergy and Clinical Immunology 128, 996-1005.
Ramsay, C. E., Hayden, C. M., Tiller, K. J., Burton, P. R., Hagel, I., Palenque, M., Lynch, N. R., Goldblatt, J. & LeSouef, P. N. (1999). Association of polymorphisms in the beta2-adrenoreceptor gene with higher levels of parasitic infection. Human Genetics 104, 269-274.
Randall, K. L., Lambe, T., Johnson, A. L., Treanor, B., Kucharska, E., Domaschenz, H., Whittle, B., Tze, L. E., Enders, A., Crockford, T. L., Bouriez-Jones, T., Alston, D., Cyster, J. G., Lenardo, M. J., Mackay, F., Deenick, E. K., Tangye, S. G., Chan, T. D., Camidge, T., Brink, R., Vinuesa, C. G., Batista, F. D., Cornall, R. J. & Goodnow, C. C. (2009). Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nature Immunology 10, 1283-1291.
Roa, S., Isidoro-Garcia, M., Davila, I., Laffond, E., Lorente, F. & Gonzalez-Sarmiento, R. (2008). Molecular analysis of activation-induced cytidine deaminase gene in immunoglobulin-E deficient patients. Clinical & Developmental Immunology 2008, 146715.
Roifman, C. M., Gu, Y. & Cohen, A. (2006). Mutations in the RNA component of RNase mitochondrial RNA processing might cause Omenn syndrome. The Journal of Allergy and Clinical Immunology 117, 897-903.
Roifman, C. M., Zhang, J., Atkinson, A., Grunebaum, E. & Mandel, K. (2008). Adenosine deaminase deficiency can present with features of Omenn syndrome. The Journal of Allergy and Clinical Immunology 121, 1056-1058.
Roongapinun, S., Oh, S. Y., Wu, F., Panthong, A., Zheng, T. & Zhu, Z. (2010). Role of SHIP-1 in the adaptive immune responses to aeroallergen in the airway. PLoS One 5, e14174.
Rothman, P. B. (2010). The transcriptional regulator NFIL3 controls IgE production. Transactions of the American Clinical and Climatological Association 121, 156-171.
Sampogna, F., Demenais, F., Hochez, J., Oryszczyn, M. P., Maccario, J., Kauffmann, F., Feingold, J. & Dizier, M. H. (2000). Segregation analysis of IgE levels in 335 French families (EGEA) using different strategies to correct for the ascertainment through a correlated trait (asthma). Genetic Epidemiology 18, 128-142.
Schedel, M., Frei, R., Bieli, C., Cameron, L., Adamski, J., Lauener, R. & Kabesch, M. (2009). An IgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression. The Journal of Allergy and Clinical Immunology 124, 583-589, 589.e1-6.
Schedl, A., Larin, Z., Montoliu, L., Thies, E., Kelsey, G., Lehrach, H. & Schutz, G. (1993). A method for the generation of YAC transgenic mice by pronuclear microinjection. Nucleic Acids Research 21, 4783-4787.
Sel, S., Rost, B. R., Yildirim, A. O., Sel, B., Kalwa, H., Fehrenbach, H., Renz, H., Gudermann, T. & Dietrich, A. (2008). Loss of classical transient receptor potential 6 channel reduces allergic airway response. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 38, 1548-1558.
Shan, G. (2010). RNA interference as a gene knockdown technique. The International Journal of Biochemistry and Cell Biology 42, 1243-1251.
Shang, X. Z., Ma, K. Y., Radewonuk, J., Li, J., Song, X. Y., Griswold, D. E., Emmell, E. & Li, L. (2006). IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-gamma-deficient mice in a Th2-biased response. Cellular Immunology 241, 66-74.
Sharma, S., Sharma, A., Kumar, S., Sharma, S. K. & Ghosh, B. (2006). Association of TNF haplotypes with asthma, serum IgE levels, and correlation with serum TNF-alpha levels. American Journal of Respiratory Cell and Molecular Biology 35, 488-495.
Shen, M., Vermeulen, R., Rajaraman, P., Menashe, I., He, X., Chapman, R. S., Yeager, M., Thomas, G., Burdett, L., Hutchinson, A., Yuenger, J., Chanock, S. & Lan, Q. (2009). Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Environmental and Molecular Mutagenesis 50, 285-290.
Shilling, R. A., Clay, B. S., Tesciuba, A. G., Berry, E. L., Lu, T., Moore, T. V., Bandukwala, H. S., Tong, J., Weinstock, J. V., Flavell, R. A., Horan, T., Yoshinaga, S. K., Welcher, A. A., Cannon, J. L. & Sperling, A. I. (2009). CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. Cellular Immunology 259, 177-184.
Shimanoe, Y., Miyazaki, Y., Hara, H., Inokuchi, A. & Yoshida, H. (2009). Amelioration of experimental allergic rhinitis with suppression of topical immune responses by lack of IL-27/WSX-1 signaling. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology 102, 223-232.
Shimoda, K., van Deursen, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A., Doherty, P. C., Grosveld, G., Paul, W. E. & Ihle, J. N. (1996). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380, 630-633.
Shugart, Y. Y., Specchia, C., Li, H. H., Doan, B. Q., Mathias, R. A. & Devoto, M. (2001). Comparison of sib pair-based approaches for identifying quantitative trait loci underlying asthma in the Busselton families. Genetic Epidemiology 21(Suppl. 1), S198-S203.
Sin, J. I., Kim, J. J., Ugen, K. E., Ciccarelli, R. B., Higgins, T. J. & Weiner, D. B. (1998). Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes. European Journal of Immunology 28, 3530-3540.
Smith, J. K., Krishnaswamy, G. H., Dykes, R., Reynolds, S. & Berk, S. L. (1997). Clinical manifestations of IgE hypogammaglobulinemia. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology 78, 313-318.
Sommers, C. L., Park, C. S., Lee, J., Feng, C., Fuller, C. L., Grinberg, A., Hildebrand, J. A., Lacana, E., Menon, R. K., Shores, E. W., Samelson, L. E. & Love, P. E. (2002). A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296, 2040-2043.
Strachan, D. P., Wong, H. J. & Spector, T. D. (2001). Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins. The Journal of Allergy and Clinical Immunology 108, 901-907.
Symula, D. J., Frazer, K. A., Ueda, Y., Denefle, P., Stevens, M. E., Wang, Z. E., Locksley, R. & Rubin, E. M. (1999). Functional screening of an asthma QTL in YAC transgenic mice. Nature Genetics 23, 241-244.
Szymczak, W. A., Sellers, R. S. & Pirofski, L. A. (2012). IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms. The American Journal of Pathology 180, 1547-1559.
Takeba, Y., Nagafuchi, H., Takeno, M., Kashiwakura, J. & Suzuki, N. (2002). Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. Journal of Immunology 168, 2365-2370.
Tamura-Yamashita, K., Endo, J., Isogai, S., Matsuoka, K., Yonekawa, H. & Yoshizawa, Y. (2008). Gamma-delta T cell is essential for allergen-induced late asthmatic response in a murine model of asthma. Journal of Medical and Dental Sciences 55, 113-120.
Threadgill, D. W., Hunter, K. W. & Williams, R. W. (2002). Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort. Mammalian Genome 13, 175-178.
Tsukuba, T., Okamoto, K., Okamoto, Y., Yanagawa, M., Kohmura, K., Yasuda, Y., Uchi, H., Nakahara, T., Furue, M., Nakayama, K., Kadowaki, T., Yamamoto, K. & Nakayama, K. I. (2003). Association of cathepsin E deficiency with development of atopic dermatitis. Journal of Biochemistry 134, 893-902.
Turul, T., Tezcan, I., Artac, H., de Bruin-Versteeg, S., Barendregt, B. H., Reisli, I., Sanal, O., van Dongen, J. J. & van der Burg, M. (2009). Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency. European Journal of Pediatrics 168, 87-93.
Vafa, M., Maiga, B., Israelsson, E., Dolo, A., Doumbo, O. K. & Troye-Blomberg, M. (2009). Impact of the IL-4 -590 C/T transition on the levels of Plasmodium falciparum specific IgE, IgG, IgG subclasses and total IgE in two sympatric ethnic groups living in Mali. Microbes and Infection/Institut Pasteur 11, 779-784.
Van Eerdewegh, P., Little, R. D., Dupuis, J., Del Mastro, R. G., Falls, K., Simon, J., Torrey, D., Pandit, S., McKenny, J., Braunschweiger, K., Walsh, A., Liu, Z., Hayward, B., Folz, C., Manning, S. P., Bawa, A., Saracino, L., Thackston, M., Benchekroun, Y., Capparell, N., Wang, M., Adair, R., Feng, Y., Dubois, J., FitzGerald, M. G., Huang, H., Gibson, R., Allen, K. M., Pedan, A., Danzig, M. R., Umland, S. P., Egan, R. W., Cuss, F. M., Rorke, S., Clough, J. B., Holloway, J. W., Holgate, S. T. & Keith, T. P. (2002). Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418, 426-430.
Vaz, E. M., Vaz, N. M. & Levine, B. B. (1971). Persistent formation of reagins in mice injected with low doses of ovalbumin. Immunology 21, 11-15.
Verra, F., Luoni, G., Calissano, C., Troye-Blomberg, M., Perlmann, P., Perlmann, H., Arca, B., Sirima, B. S., Konate, A., Coluzzi, M., Kwiatkowski, D. & Modiano, D. (2004). IL4-589C/T polymorphism and IgE levels in severe malaria. Acta Tropica 90, 205-209.
Villa, A., Santagata, S., Bozzi, F., Giliani, S., Frattini, A., Imberti, L., Gatta, L. B., Ochs, H. D., Schwarz, K., Notarangelo, L. D., Vezzoni, P. & Spanopoulou, E. (1998). Partial V(D)J recombination activity leads to Omenn syndrome. Cell 93, 885-896.
Wan, Y. I., Strachan, D. P., Evans, D. M., Henderson, J., McKeever, T., Holloway, J. W., Hall, I. P. & Sayers, I. (2011). A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom. The Journal of Allergy and Clinical Immunology 127, 223-231.
Warr, G. W., Magor, K. E. & Higgins, D. A. (1995). IgY: clues to the origins of modern antibodies. Immunology Today 16, 392-398.
Watanabe, T., Okano, M., Hattori, H., Yoshino, T., Ohno, N., Ohta, N., Sugata, Y., Orita, Y., Takai, T. & Nishizaki, K. (2004). Roles of FcgammaRIIB in nasal eosinophilia and IgE production in murine allergic rhinitis. American Journal of Respiratory and Critical Care Medicine 169, 105-112.
Watford, W. T., Wang, C. C., Tsatsanis, C., Mielke, L. A., Eliopoulos, A. G., Daskalakis, C., Charles, N., Odom, S., Rivera, J., O'Shea, J. & Tsichlis, P. N. (2010). Ablation of tumor progression locus 2 promotes a type 2 Th cell response in ovalbumin-immunized mice. Journal of Immunology 184, 105-113.
Weidinger, S., Gieger, C., Rodriguez, E., Baurecht, H., Mempel, M., Klopp, N., Gohlke, H., Wagenpfeil, S., Ollert, M., Ring, J., Behrendt, H., Heinrich, J., Novak, N., Bieber, T., Kramer, U., Berdel, D., von Berg, A., Bauer, C. P., Herbarth, O., Koletzko, S., Prokisch, H., Mehta, D., Meitinger, T., Depner, M., von Mutius, E., Liang, L., Moffatt, M., Cookson, W., Kabesch, M., Wichmann, H. E. & Illig, T. (2008). Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genetics 4, e1000166.
Weih, F., Warr, G., Yang, H. & Bravo, R. (1997). Multifocal defects in immune responses in RelB-deficient mice. Journal of Immunology 158, 5211-5218.
Wenderfer, S. E., Slack, J. P., McCluskey, T. S. & Monaco, J. J. (2000). Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11. Genomics 63, 354-373.
Wesemann, D. R., Magee, J. M., Boboila, C., Calado, D. P., Gallagher, M. P., Portuguese, A. J., Manis, J. P., Zhou, X., Recher, M., Rajewsky, K., Notarangelo, L. D. & Alt, F. W. (2011). Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. The Journal of Experimental Medicine 208, 2733-2746.
Wheeler, E., Miller, E. N., Peacock, C. S., Donaldson, I. J., Shaw, M. A., Jamieson, S. E., Blackwell, J. M. & Cordell, H. J. (2006). Genome-wide scan for loci influencing quantitative immune response traits in the Belem family study: comparison of methods and summary of results. Annals of Human Genetics 70, 78-97.
Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J. L., Buist, N., Levy-Lahad, E., Mazzella, M., Goulet, O., Perroni, L., Bricarelli, F. D., Byrne, G., McEuen, M., Proll, S., Appleby, M. & Brunkow, M. E. (2001). X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nature Genetics 27, 18-20.
Williams-Blangero, S., VandeBerg, J. L., Subedi, J., Aivaliotis, M. J., Rai, D. R., Upadhayay, R. P., Jha, B. & Blangero, J. (2002). Genes on chromosomes 1 and 13 have significant effects on Ascaris infection. Proceedings of the National Academy of Sciences of the United States of America 99, 5533-5538.
Wjst, M., Fischer, G., Immervoll, T., Jung, M., Saar, K., Rueschendorf, F., Reis, A., Ulbrecht, M., Gomolka, M., Weiss, E. H., Jaeger, L., Nickel, R., Richter, K., Kjellman, N. I., Griese, M., von Berg, A., Gappa, M., Riedel, F., Boehle, M., van Koningsbruggen, S., Schoberth, P., Szczepanski, R., Dorsch, W., Silbermann, M., Wichmann, H. E., et al. (1999). A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 58, 1-8.
Woellner, C., Gertz, E. M., Schaffer, A. A., Lagos, M., Perro, M., Glocker, E. O., Pietrogrande, M. C., Cossu, F., Franco, J. L., Matamoros, N., Pietrucha, B., Heropolitanska-Pliszka, E., Yeganeh, M., Moin, M., Espanol, T., Ehl, S., Gennery, A. R., Abinun, M., Breborowicz, A., Niehues, T., Kilic, S. S., Junker, A., Turvey, S. E., Plebani, A., Sanchez, B., Garty, B. Z., Pignata, C., Cancrini, C., Litzman, J., Sanal, O., Baumann, U., Bacchetta, R., Hsu, A. P., Davis, J. N., Hammarstrom, L., Davies, E. G., Eren, E., Arkwright, P. D., Moilanen, J. S., Viemann, D., Khan, S., Marodi, L., Cant, A. J., Freeman, A. F., Puck, J. M., Holland, S. M. & Grimbacher, B. (2010). Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome. The Journal of Allergy and Clinical Immunology 125, 424-432.
Wrensch, M., Wiencke, J. K., Wiemels, J., Miike, R., Patoka, J., Moghadassi, M., McMillan, A., Kelsey, K. T., Aldape, K., Lamborn, K. R., Parsa, A. T., Sison, J. D. & Prados, M. D. (2006). Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Research 66, 4531-4541.
Xiong, H., Dolpady, J., Wabl, M., Curotto de Lafaille, M. A. & Lafaille, J. J. (2012). Sequential class switching is required for the generation of high affinity IgE antibodies. The Journal of Experimental Medicine 209, 353-364.
Xu, X., Fang, Z., Wang, B., Chen, C., Guang, W., Jin, Y., Yang, J., Lewitzky, S., Aelony, A., Parker, A., Meyer, J. & Weiss, S. T. (2001). A genomewide search for quantitative-trait loci underlying asthma. American Journal of Human Genetics 69, 1271-1277.
Xu, J., Postma, D. S., Howard, T. D., Koppelman, G. H., Zheng, S. L., Stine, O. C., Bleecker, E. R. & Meyers, D. A. (2000). Major genes regulating total serum immunoglobulin E levels in families with asthma. American Journal of Human Genetics 67, 1163-1173.
Yabiku, K., Hayashi, M., Komiya, I., Yamada, T., Kinjo, Y., Ohshiro, Y., Kouki, T. & Takasu, N. (2007). Polymorphisms of interleukin (IL)-4 receptor alpha and signal transducer and activator of transcription-6 (Stat6) are associated with increased IL-4Ralpha-Stat6 signalling in lymphocytes and elevated serum IgE in patients with Graves' disease. Clinical and Experimental Immunology 148, 425-431.
Yamada, T., Sato, A., Komiya, I., Nishimori, T., Ito, Y., Terao, A., Eto, S. & Tanaka, Y. (2000). An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. The Journal of Clinical Endocrinology and Metabolism 85, 2775-2778.
Yamatomo, T., Okano, M., Ono, T., Nakayama, E., Yoshino, T., Satoskar, A. R., Harn, D. A. Jr. & Nishizaki, K. (2001). Sex-related differences in the initiation of allergic rhinitis in mice. Allergy 56, 525-531.
Yang, K. D., Liu, C. A., Chang, J. C., Chuang, H., Ou, C. Y., Hsu, T. Y. & Wang, C. L. (2004). Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 34, 32-37.
Yang, W. C. & Olive, D. (1999). Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway. European Journal of Immunology 29, 1842-1849.
Ye, B. H., Cattoretti, G., Shen, Q., Zhang, J., Hawe, N., de Waard, R., Leung, C., Nouri-Shirazi, M., Orazi, A., Chaganti, R. S., Rothman, P., Stall, A. M., Pandolfi, P. P. & Dalla-Favera, R. (1997). The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nature Genetics 16, 161-170.
Yokouchi, Y., Nukaga, Y., Shibasaki, M., Noguchi, E., Kimura, K., Ito, S., Nishihara, M., Yamakawa-Kobayashi, K., Takeda, K., Imoto, N., Ichikawa, K., Matsui, A., Hamaguchi, H. & Arinami, T. (2000). Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 66, 152-160.
Yokouchi, Y., Shibasaki, M., Noguchi, E., Nakayama, J., Ohtsuki, T., Kamioka, M., Yamakawa-Kobayashi, K., Ito, S., Takeda, K., Ichikawa, K., Nukaga, Y., Matsui, A., Hamaguchi, H. & Arinami, T. (2002). A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families. Genes and Immunity 3, 9-13.
Yoo, J., Omori, M., Gyarmati, D., Zhou, B., Aye, T., Brewer, A., Comeau, M. R., Campbell, D. J. & Ziegler, S. F. (2005). Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. The Journal of Experimental Medicine 202, 541-549.
Yoshimoto, T., Nagai, N., Ohkusu, K., Ueda, H., Okamura, H. & Nakanishi, K. (1998). LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2R beta+T cells. Journal of Immunology 161, 1483-1492.
Yoshioka, T., Imura, K., Asakawa, M., Suzuki, M., Oshima, I., Hirasawa, T., Sakata, T., Horikawa, T. & Arimura, A. (2009). Impact of the Gly573Ser substitution in TRPV3 on the development of allergic and pruritic dermatitis in mice. The Journal of Investigative Dermatology 129, 714-722.
Zhang, Q., Davis, J. C., Lamborn, I. T., Freeman, A. F., Jing, H., Favreau, A. J., Matthews, H. F., Davis, J., Turner, M. L., Uzel, G., Holland, S. M. & Su, H. C. (2009). Combined immunodeficiency associated with DOCK8 mutations. The New England Journal of Medicine 361, 2046-2055.
Zhang, Y., Leaves, N. I., Anderson, G. G., Ponting, C. P., Broxholme, J., Holt, R., Edser, P., Bhattacharyya, S., Dunham, A., Adcock, I. M., Pulleyn, L., Barnes, P. J., Harper, J. I., Abecasis, G., Cardon, L., White, M., Burton, J., Matthews, L., Mott, R., Ross, M., Cox, R., Moffatt, M. F. & Cookson, W. O. (2003). Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nature Genetics 34, 181-186.
Zhang, X., Schmudde, I., Laumonnier, Y., Pandey, M. K., Clark, J. R., Konig, P., Gerard, N. P., Gerard, C., Wills-Karp, M. & Kohl, J. (2010). A critical role for C5L2 in the pathogenesis of experimental allergic asthma. Journal of Immunology 185, 6741-6752.
Zhang, D. H., Yang, L., Cohn, L., Parkyn, L., Homer, R., Ray, P. & Ray, A. (1999). Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11, 473-482.
Zotos, D., Coquet, J. M., Zhang, Y., Light, A., D'Costa, K., Kallies, A., Corcoran, L. M., Godfrey, D. I., Toellner, K. M., Smyth, M. J., Nutt, S. L. & Tarlinton, D. M. (2010). IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. The Journal of Experimental Medicine 207, 365-378.
Zuberi, R. I., Hsu, D. K., Kalayci, O., Chen, H. Y., Sheldon, H. K., Yu, L., Apgar, J. R., Kawakami, T., Lilly, C. M. & Liu, F. T. (2004). Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. The American Journal of Pathology 165, 2045-2053.
