[en] The thyrogastric autoimmune syndrome (TAS) was described in patients in whom the serum cross-reacted both with gastric parietal cells antigens and thyroid antigens.
We describe several cases illustrating the spectrum of pathogical features of TAS. Autoimmune thyroiditis include Hahimoto’s Thyroiditis and Graves Disease. Autoimmune gastritis may present at first only micronutrients deficiency (B12, iron) whereas Biermer anemia with gastric atrophy and gastrin cell hyperplasia is the consequence of long standing disease. One possible presentation of gastric autoimmunity is the association with Helicobacter pylori infection. Gastric autoimmunity is potentially reversible if Helicobacter is erradicated. When gastric autoimmunity is irreversible, this condition leads to gastric severe atrophy, hypochlorhydria and hypergastrinemia. Hypergastrinemia stimulates enterochromaffin cell hyperplasia, progressing eventually to neuroendocrine tumors. The thyrogastric syndrome should be considered a risk factor to develop a neuuroendocrine tumor.
We propose a diagnostic approach to improve the characterization of TAS. We review the literature on the subject and discuss some interesting animal models of infectious gastric autoimmunity
