Article (Scientific journals)
Muscle: a source of progenitor cells for bone fracture healing.
Henrotin, Yves
2011In BMC Medicine, 9, p. 136
Peer Reviewed verified by ORBi
 

Files


Full Text
BMC Muscle progenitor 1741-7015-9-136.pdf
Publisher postprint (178.86 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Fracture Healing/physiology; Fractures, Closed/pathology; Fractures, Open/pathology; Humans; Muscle Cells/pathology; Osteogenesis/physiology; Stem Cells/pathology
Abstract :
[en] Bone repair failure is a major complication of open fracture, leading to non-union of broken bone extremities and movement at the fracture site. This results in a serious disability for patients. The role played by the periosteum and bone marrow progenitors in bone repair is now well documented. In contrast, limited information is available on the role played by myogenic progenitor cells in bone repair. In a recent article published in BMC Musculoskeletal Disorders, Liu et al. compared the presence of myogenic progenitor (MyoD lineage cells) in closed and open fractures. They showed that myogenic progenitors are present in open, but not closed fractures, suggesting that muscle satellite cells may colonize the fracture site in the absence of intact periosteum. Interestingly, these progenitors sequentially expressed a chondrogenic and, thereafter, an osteoblastic phenotype, suggestive of a functional role in the repair process. This finding opens up new perspectives for the research of orthopedic surgical methods, which could maximize myogenic progenitor access and mobilization to augment bone repair. Please see related article: http://www.biomedcentral.com/1471-2474/12/288.
Disciplines :
Surgery
Author, co-author :
Henrotin, Yves  ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Language :
English
Title :
Muscle: a source of progenitor cells for bone fracture healing.
Publication date :
2011
Journal title :
BMC Medicine
eISSN :
1741-7015
Publisher :
BioMed Central, United Kingdom
Volume :
9
Pages :
136
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 July 2014

Statistics


Number of views
58 (1 by ULiège)
Number of downloads
98 (0 by ULiège)

Scopus citations®
 
10
Scopus citations®
without self-citations
10
OpenCitations
 
10

Bibliography


Similar publications



Contact ORBi