Reference : Treatment of drug-induced toxic epidermal necrolysis (Lyell’s syndrome) with intraven...
Scientific journals : Article
Human health sciences : Dermatology
Human health sciences : Anesthesia & intensive care
Treatment of drug-induced toxic epidermal necrolysis (Lyell’s syndrome) with intravenous human immunoglobulins
Paquet, Philippe mailto [Université de Liège - ULg > > Dermatopathologie >]
Jacob, Emilie mailto [Université de Liège - ULg > Administration de l'enseignement et des étudiants > AEE : Cellule programmes des cours - Diplômes >]
Damas, Pierre mailto [Université de Liège - ULg > > Soins intensifs >]
Pierard, Gérald mailto [Université de Liège - ULg > > Dermatopathologie >]
Burns : Journal of the International Society for Burn Injuries
Yes (verified by ORBi)
New York
[en] Toxic epidermal necrolysis ; Lyell’s syndrome ; Immunoglobulin ; Apoptosis
[en] Toxic epidermal necrolysis (TEN) is a rare drug-induced life-threatening disease. Currently, the disease is only treated by supportive and antiseptic measures. Quite recently intravenous immunoglobulins (IG) were shown to be a promising TEN treatment. The rationale for their use is based on the fact that keratinocyte apoptosis in TEN involves the CD95 (APO-1/Fas) cell
surface receptor–ligand system. We successfully treated a TEN patient with high dose of intravenous IG. The clinical recovery appeared exceptionally rapid. Immunohistochemistry showed that the IG action probably developed on the CD95 receptor–ligand system at the keratinocytes surface.
Researchers ; Professionals

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