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Poster (Scientific congresses and symposiums)
Stereoselective synthesis of peptidoglycan fragments on solid support
Simon, Justine; Lamborelle, Nicolas; Joris, Bernard et al.
201415th Tetrahedron Symposium Challenges in Bioorganic and Organic Medicinal Chemistry
 

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Keywords :
peptidoglycan; Solid-Phase Peptide Synthesis; Cross Metathesis
Abstract :
[en] The mammalian proteins, Nod1 and Nod2, are able to recognize peptidoglycan motifs during bacterial infection. Interestingly, Nod1 is a detector of peptides and muropeptides containing the meso-2,6-diaminopimelic acid (m-A2pm), a non-proteinogenic amino acid found in Gram- bacteria. In this work, we describe a synthesis of peptidoglycan motifs entirely on solid support. Solid-Phase Peptide Synthesis (SPPS), Cross Metathesis (CM) and sugar chemistry are three methods to anchor respectively amino acids, m-A2pm and sugars derivatives on a resin as solid support.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Chemistry
Author, co-author :
Simon, Justine ;  Université de Liège - ULiège > Form. doct. sc. (chimie - Bologne)
Lamborelle, Nicolas ;  Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Joris, Bernard ;  Université de Liège - ULiège > Département des sciences de la vie > Physiologie et génétique bactériennes
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Language :
English
Title :
Stereoselective synthesis of peptidoglycan fragments on solid support
Publication date :
June 2014
Event name :
15th Tetrahedron Symposium Challenges in Bioorganic and Organic Medicinal Chemistry
Event organizer :
elsevier
Event place :
Londres, United Kingdom
Event date :
24 juin 2014 au 27 juin 2014
Audience :
International
Name of the research project :
Modeling of the Network Regulating BlaP β-Lactamase Induction
Funders :
ARC
Available on ORBi :
since 07 July 2014

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