Article (Scientific journals)
Wiktor stent for treatment of chronic total coronary artery occlusions: short- and long-term clinical and angiographic results from a large multicenter experience.
Anzuini, A.; Rosanio, S.; Legrand, Victor et al.
1998In Journal of the American College of Cardiology, 31 (2), p. 281-8
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Keywords :
Analysis of Variance; Angioplasty, Balloon, Coronary/adverse effects; Anticoagulants/therapeutic use; Aspirin/therapeutic use; Catheterization, Peripheral/adverse effects; Confidence Intervals; Coronary Angiography; Coronary Disease/pathology/radiography/therapy; Equipment Design; Female; Follow-Up Studies; Hemorrhage/etiology; Humans; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction/etiology; Myocardial Revascularization; Odds Ratio; Platelet Aggregation Inhibitors/therapeutic use; Recurrence; Stents; Survival Rate; Thrombosis/etiology; Ticlopidine/therapeutic use; Treatment Outcome; Warfarin/therapeutic use
Abstract :
[en] OBJECTIVES: This study reports the first multicenter experience with the Wiktor coil stent for treatment of chronic total coronary artery occlusions (CTOs). BACKGROUND: Percutaneous transluminal coronary angioplasty (PTCA) of CTO is associated with very high restenosis and reocclusion rates. Coronary stenting has been proposed as a means of improving outcome. However, the Wiktor device for CTOs has never been tested in a large patient sample. METHODS: From January 1993 to December 1996, 89 patients with 91 CTOs underwent Wiktor stent implantation after successful PTCA. The post-stenting regimen consisted of warfarin (Coumadin) plus aspirin in the initial 49 patients (55%) and aspirin plus ticlopidine in 40 patients (45%). RESULTS: Stenting was successful in 87 patients (98%). At 1 month, 6% of patients had subacute stent thrombosis, 3% had a major bleeding event, and 1% had access-site complications. Subacute stent thrombosis showed univariate association with warfarin therapy (p = 0.009). Angiographic follow-up was obtained in 76 (93%) of 82 eligible patients. The restenosis rate was 32%, including 4% reocclusions. By multiple logistic regression analysis, restenosis was independently associated with multiple stents (adjusted odds ratio [OR] 27.67, 95% confidence interval [CI] 4.25 to 79.95, p = 0.0008) and increasing values of occlusion length (adjusted OR 1.23, 95% CI 1.09 to 1.39, p = 0.001). Freedom from death, myocardial infarction or stented vessel revascularization was 87% and 72% at 1 and 3 years, respectively. CONCLUSIONS: Short- and long-term clinical and angiographic outcomes are favorable in patients undergoing Wiktor stent implantation in CTO. Further technical improvement is needed to reduce the restenosis rate in patients with long lesions and multiple stents.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Anzuini, A.
Rosanio, S.
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Tocchi, M.
Coppi, R.
Bonnier, H.
Sheiban, I.
Kulbertus, Henri ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Chierchia, S. L.
Language :
English
Title :
Wiktor stent for treatment of chronic total coronary artery occlusions: short- and long-term clinical and angiographic results from a large multicenter experience.
Publication date :
1998
Journal title :
Journal of the American College of Cardiology
ISSN :
0735-1097
eISSN :
1558-3597
Publisher :
Elsevier, Netherlands
Volume :
31
Issue :
2
Pages :
281-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 June 2014

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