Article (Scientific journals)
Prognostic significance of electrocardiographic findings in angina at rest. Therapeutic implications.
Demoulin, J. C.; Bertholet, M.; Chevigne, M. et al.
1981In British Heart Journal, 46 (3), p. 320-4
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Keywords :
Adrenergic beta-Antagonists/therapeutic use; Adult; Aged; Amiodarone/therapeutic use; Angina Pectoris/complications/drug therapy/physiopathology; Coronary Angiography; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction/etiology; Nifedipine/therapeutic use; Prognosis
Abstract :
[en] Ninety-five patients with angina at rest were observed in the coronary care unit. Eighty-one per cent presented concomitantly or had previously presented some other manifestations of coronary artery disease. These patients were divided into two subgroups. In subgroup 1 (40 patients), episodes of non-exertional angina were associated with a pattern of hyperacute subepicardial injury and, frequently, with ventricular arrhythmias. In subgroup 2 (55 patients), the episodes of angina at rest were attended by horizontal ST depression, isolated T wave inversion, or trivial ST-T changes. Coronary angiographic findings were similar in both subgroups. Symptoms regressed in only 9% of patients in subgroup 1 while they were receiving beta-receptor antagonists, whereas amiodarone alone or amiodarone with nifedipine was successful in 58%. Of these patients, 25% developed a myocardial infarction shortly after admission. In subgroup 2 patients, beta-blockers were successful in 61%. Amiodarone isolated or associated with nifedipine was successful in 55% of the patients in whom it was tried. Only 5% of patients in this subgroup developed a myocardial infarction during their hospital stay. It is concluded that: (1) observation of the electrocardiogram during spontaneous angina in patients with known atherosclerotic coronary heart disease may be of prognostic significance and may influence therapeutic decision. (2) Amiodarone by virtue of its anginal and antiarrhythmic properties may be particularly useful in the treatment of non-exertional angina.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Demoulin, J. C.
Bertholet, M.
Chevigne, M.
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Renier, J.
Soumagne, D.
Soyeur, D.
Limet, R.
Kulbertus, Henri ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Prognostic significance of electrocardiographic findings in angina at rest. Therapeutic implications.
Publication date :
1981
Journal title :
British Heart Journal
ISSN :
0007-0769
Publisher :
BMJ Publishing Group, United Kingdom
Volume :
46
Issue :
3
Pages :
320-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 June 2014

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