No full text
Article (Scientific journals)
Defective regulation of cerebral oxygen transport after severe birth asphyxia
RAMAEKERS, Vincent; Casaer, P.
1990In Developmental Medicine and Child Neurology, 32 (1), p. 56-62
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
Asphyxia Neonatorum/metabolism/physiopathology; Cerebrovascular Circulation; Gestational Age; Humans; Infant, Newborn; Oxygen/blood; Ultrasonography
Abstract :
[en] Cerebral artery Doppler ultrasonography was used to study the cerebral blood-flow velocity and cerebral oxygen transport of infants requiring a blood transfusion to correct anaemia. Mean flow velocity, pulsatility index and haemoglobin concentration were determined before and after transfusion. 11 stable preterm infants demonstrated an inverse relationship between haemoglobin concentration (or estimated arterial oxygen content) and mean flow velocity, indicating the presence of a homeostatic mechanism keeping brain oxygen transport within certain limits. Three infants with severe post-asphyxial encepalopathy had relatively high mean flow velocities and low pulsatility indices both before and after transfusion. There were no circulatory adjustments in response to an increase in haemoglobin concentration. Thus severe asphyxia at birth disrupted the homeostatic mechanism responsible for keeping brain oxygen transport constant. These findings stress the importance of close monitoring of arterial oxygen content, particularly for infants with severe post-asphyxial encephalopathy.
Disciplines :
Pediatrics
Neurology
Author, co-author :
RAMAEKERS, Vincent ;  1Department of Neuropaediatrics, RWTH, University of Aachen, West Germany
Casaer, P.
Language :
English
Title :
Defective regulation of cerebral oxygen transport after severe birth asphyxia
Publication date :
January 1990
Journal title :
Developmental Medicine and Child Neurology
ISSN :
0012-1622
eISSN :
1469-8749
Publisher :
Wiley-Blackwell, United States
Volume :
32
Issue :
1
Pages :
56-62
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 June 2014

Statistics


Number of views
40 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
14
Scopus citations®
without self-citations
14
OpenCitations
 
15

Bibliography


Similar publications



Contact ORBi