ORBi: Carmeliet Peter - Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

Reference : Synergism between vascular endothelial growth factor and placental growth factor contrib...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Anatomy (cytology, histology, embryology...) & physiology
	To cite this reference:	http://hdl.handle.net/2268/16915

Title :	Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
Language :	English
Author, co-author :	Carmeliet, Peter [ > > ]
	Moons, Lieve [ > > ]
	Luttun, Aernout [ > > ]
	Vincenti [ > > ]
	Compernolle, Veerle [ > > ]
	De mol, Maria [ > > ]
	Wu, Yan [ > > ]
	Bono, Françoise [ > > ]
	Devy, Laetitia [ > > ]
	Beck, Heike [ > > ]
	Scholz, Dimitri [ > > ]
	Acker, Till [ > > ]
	Dipalma, Tina [ > > ]
	Dewerchin, Mieke [ > > ]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Stalmans, Ingeborg [ > > ]
	Barra, Adriano [ > > ]
	Blacher, Silvia [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Vandendriessche, Thierry [ > > ]
	Ponten, Anica [ > > ]
	Eriksson, Ulf [ > > ]
	Plate, Karl H [ > > ]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
	Schaper [ > > ]
	Charnock-Jones, Stephen [ > > ]
	Hicklin, Daniel [ > > ]
	Herbert, Jean-Marc [ > > ]
	Collen, Désiré [ > > ]
	Persico, Graziella [ > > ]
Publication date :	2001
Journal title :	Nature Medicine
Publisher :	Nature Publishing Group
Volume :	7
Issue/season :	5
Pages :	575-583
Audience :	International
ISSN :	1078-8956
e-ISSN :	1546-170X
City :	New York
Country :	NY
Abstract :	[en] Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. Both VEGF and PlGF bind to VEGF receptor-1 (VEGFR-1), but it is unknown whether VEGFR-1, which exists as a soluble or a membrane-bound type, is an inert decoy or a signaling receptor for PlGF during angiogenesis. Here, we report that embryonic angiogenesis in mice was not affected by deficiency of PlGF (Pgf -/-). VEGF-B, another ligand of VEGFR-1, did not rescue development in Pgf -/- mice. However, loss of PlGF impaired angiogenesis, plasma extravasation and collateral growth during ischemia, inflammation, wound healing and cancer. Transplantation of wild-type bone marrow rescued the impaired angiogenesis and collateral growth in Pgf -/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow−derived cells. The synergism between PlGF and VEGF was specific, as PlGF deficiency impaired the response to VEGF, but not to bFGF or histamine. VEGFR-1 was activated by PlGF, given that anti-VEGFR-1 antibodies and a Src-kinase inhibitor blocked the endothelial response to PlGF or VEGF/PlGF. By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders.
Permalink :	http://hdl.handle.net/2268/16915
DOI :	10.1038/87904

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