Reference : Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/1690
Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation
English
Navet, Rachel mailto [Université de Liège - ULg > > GIGA - Formation >]
Mathy, Grégory [Université de Liège - ULg > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
Douette, Pierre [Université de Liège - ULg > > Bioénergétique et physiologie cellulaire >]
Dobson, Rowan mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie physique, spectrométrie de masse >]
Leprince, Pierre mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
De Pauw, Edwin mailto [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
Sluse-Goffart, C. [> > > >]
Sluse, Francis mailto [Université de Liège - ULg > Département des sciences de la vie > Bioénergétique et physiologie cellulaire >]
5-Jan-2007
Journal of Proteome Research
Amer Chemical Soc
6
1
25-33
Yes (verified by ORBi)
International
1535-3893
Washington
[en] proteomics ; 2 D-DIGE ; brown adipose tissue ; uncoupling protein 1 ; cold acclimation ; thermogenesis
[en] Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling.
Researchers ; Students
http://hdl.handle.net/2268/1690

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