Article (Scientific journals)
Micro-Computed Tomography Based Computational Fluid Dynamics for the Determination of Shear Stresses in Scaffolds Within a Perfusion Bioreactor
Zermatten, Emilie; Vetsch, Jolanda Rita; Ruffoni, Davide et al.
2014In Annals of Biomedical Engineering, 42 (5), p. 1085-1094
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Keywords :
Scaffold; Bone tissue engineering; Perfusion bioreactor; Computational fluid dynamics; Direct pore-level simulations
Abstract :
[en] Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk fibroin (SF) scaffold with an irregular network of interconnected pores. Their complex 3D geometries are imaged by micro-computed tomography and used in direct pore-level simulations of the entire scaffold-bioreactor system to numerically solve the governing mass and momentum conservation equations for fluid flow through porous media. The velocity field and wall shear stress distribution are determined for both scaffolds. The PCL scaffold exhibited an asymmetric distribution with peak and plateau, while the SF scaffold exhibited a homogenous distribution and conditioned the flow more efficiently than the PCL scaffold. The methodology guides the design and optimization of the scaffold geometry.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Zermatten, Emilie;  ETH, Inst Energy Technol, Zurich, Switzerland.
Vetsch, Jolanda Rita;  ETH, Inst Biomech, Zurich, Switzerland.
Ruffoni, Davide  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
Hofmann, Sandra;  ETH, Inst Biomech, Zurich, Switzerland.
Mueller, Ralph;  ETH, Inst Biomech, Zurich, Switzerland.
Steinfeld, Aldo;  ETH, Inst Energy Technol, Zurich, Switzerland.
Language :
English
Title :
Micro-Computed Tomography Based Computational Fluid Dynamics for the Determination of Shear Stresses in Scaffolds Within a Perfusion Bioreactor
Publication date :
2014
Journal title :
Annals of Biomedical Engineering
ISSN :
0090-6964
eISSN :
1573-9686
Publisher :
Springer, New York, United States - New York
Volume :
42
Issue :
5
Pages :
1085-1094
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
European Union [BIODESIGN FP7-NMP-2010-LARGE-4]
Commentary :
The authors gratefully acknowledge financial support from the European Union (BIODESIGN FP7-NMP-2010-LARGE-4). We thank H. Fries and A. Haselbacher for their support with the computational grid generation.
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since 09 June 2014

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