Article (Scientific journals)
Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling in endotoxic shock
Lambermont, Bernard; Kolh, Philippe; Ghuysen, Alexandre et al.
2004In Shock, 21 (1), p. 45-51
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Keywords :
hemodynamics; pigs; pulmonary circulation; right ventricular dysfunction; septic shock
Abstract :
[en] We investigated the effects of a dual thromboxane (TX)A(2) synthase inhibitor and TXA(2) receptor antagonist (BM-573) on right ventricular-arterial coupling in a porcine model of endotoxic shock. Thirty minutes before the onset of 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with a placebo solution, and six other pigs (Anta group) with BM-573. Right ventricular pressure-volume loops were obtained by the conductance catheter technique. The slope (E-es) of the end-systolic pressure-volume relationship and its volume intercept at 25 mmHg were calculated as measures of right ventricular systolic function. RV afterload was quantified by pulmonary arterial elastance (E-a), and E-es/E-a ratio represented right ventricular-arterial coupling. Mechanical efficiency was defined as the ratio of stroke work and pressure-volume area. In this model of endotoxic shock, BM-573 blunted the early phase of pulmonary hypertension, improved arterial oxygenation, and prevented a decrease in right ventricular myocardial efficiency and right ventricular dilatation. However, the drug could not prevent the loss of homeometric regulation and alterations in right ventricular-arterial coupling. In conclusion, dual TXA(2) synthase inhibitor and receptor antagonists such as BM-573 have potential therapeutic applications, improving right ventricular efficiency and arterial oxygenation in endotoxic shock.
Disciplines :
Anesthesia & intensive care
Hematology
Author, co-author :
Lambermont, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Kolh, Philippe  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et pathologiques
Ghuysen, Alexandre ;  Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière
Segers, P.
Dogné, Jean-Michel ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Tchana-Sato, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Morimont, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Benoit, P.
Gérard, Paul ;  Université de Liège - ULiège > Département de mathématique > Statistique (aspects expérimentaux)
Masereel, B.
D'Orio, Vincenzo ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.
Language :
English
Title :
Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling in endotoxic shock
Publication date :
January 2004
Journal title :
Shock
ISSN :
1073-2322
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
21
Issue :
1
Pages :
45-51
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 July 2009

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