Reference : Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling i...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Hematology
http://hdl.handle.net/2268/16885
Effect of a novel thromboxane A(2) inhibitor on right ventricular-arterial coupling in endotoxic shock
English
Lambermont, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et pathologiques > >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière]
Segers, P. [> > > >]
Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Morimont, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Benoit, P. [> > > >]
Gérard, Paul mailto [Université de Liège - ULg > Département de mathématique > Statistique (aspects expérimentaux) >]
Masereel, B. [> > > >]
D'Orio, Vincenzo mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Jan-2004
Shock
Lippincott Williams & Wilkins
21
1
45-51
Yes (verified by ORBi)
International
1073-2322
Philadelphia
[en] hemodynamics ; pigs ; pulmonary circulation ; right ventricular dysfunction ; septic shock
[en] We investigated the effects of a dual thromboxane (TX)A(2) synthase inhibitor and TXA(2) receptor antagonist (BM-573) on right ventricular-arterial coupling in a porcine model of endotoxic shock. Thirty minutes before the onset of 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with a placebo solution, and six other pigs (Anta group) with BM-573. Right ventricular pressure-volume loops were obtained by the conductance catheter technique. The slope (E-es) of the end-systolic pressure-volume relationship and its volume intercept at 25 mmHg were calculated as measures of right ventricular systolic function. RV afterload was quantified by pulmonary arterial elastance (E-a), and E-es/E-a ratio represented right ventricular-arterial coupling. Mechanical efficiency was defined as the ratio of stroke work and pressure-volume area. In this model of endotoxic shock, BM-573 blunted the early phase of pulmonary hypertension, improved arterial oxygenation, and prevented a decrease in right ventricular myocardial efficiency and right ventricular dilatation. However, the drug could not prevent the loss of homeometric regulation and alterations in right ventricular-arterial coupling. In conclusion, dual TXA(2) synthase inhibitor and receptor antagonists such as BM-573 have potential therapeutic applications, improving right ventricular efficiency and arterial oxygenation in endotoxic shock.
Researchers
http://hdl.handle.net/2268/16885
http://www.shockjournal.com/pt/re/shock/home.htm;jsessionid=JKRC6lFny4ChLh9nSf7tgCQVDvBZxFn39c1vQTxBhJYpjF1yMv1G!-1035908147!181195628!8091!-1

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