[en] Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 muM.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Gros, Emmanuelle
Al-Mourabit, Ali
Martin, Marie-Therese
Sorres, Jonathan
Vacelet, Jean
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Aknin, Maurice
Kashman, Yoel
Gauvin-Bialecki, Anne
Language :
English
Title :
Netamines H-N, Tricyclic Alkaloids from the Marine Sponge Biemna laboutei and Their Antimalarial Activity.
Publication date :
April 2014
Journal title :
Journal of Natural Products
ISSN :
0163-3864
eISSN :
1520-6025
Publisher :
American Chemical Society, Washington, United States - District of Columbia
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