Article (Scientific journals)
Importance of clean-up for comparison of TEQ-values obtained by CALUX and chemo-analysis
Van Wouwe, N.; Windal, I.; Vanderperren, H. et al.
2004In Talanta, 63 (5), p. 1269-1272
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Keywords :
CALUX; fractionation; human plasma; dioxin-like compounds
Abstract :
[en] This paper presents Chemically Activated LUciferine gene eXpression (CALUX) TEQ-values obtained for nine plasma samples following two different purification procedures, one of them involving fractionation. CALUX results obtained for the dioxin (DX) and dioxin + PCB (DX + PCB) fractions were then compared to the GC-HRMS TEQ-values calculated for the 17 polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (17 PCDD/F) and 17 PCDD/F + 4 cPCB congeners, respectively. The overestimation of the CALUX (DX fraction) TEQ-values in comparison with the chemo-analyses of the 17 PCDD/F is mainly explained by the presence of other AhR agonists, like brominated compounds. Otherwise, the constancy of the CALUX (DX + PCB fraction) TEQ-value which compares to increasing the GC-HRMS (17 PCDD/F + 4 cPCB) TEQ results raises questions concerning (1) the significance of CALUX results obtained without fractionation as well as (2) the toxicological effect of a cocktail of contaminants on the human health. (C) 2004 Elsevier B.V. All rights reserved.
Disciplines :
Chemistry
Author, co-author :
Van Wouwe, N.
Windal, I.
Vanderperren, H.
Eppe, Gauthier  ;  Université de Liège - ULiège > Centre interfac. d'analyse des résidus en traces (CART)
Xhrouet, Céline ;  Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
De Pauw, Edwin  ;  Université de Liège - ULiège > Chimie physique, spectrométrie de masse
Goeyens, L.
Baeyens, W.
Language :
English
Title :
Importance of clean-up for comparison of TEQ-values obtained by CALUX and chemo-analysis
Publication date :
08 August 2004
Journal title :
Talanta
ISSN :
0039-9140
eISSN :
1873-3573
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
63
Issue :
5
Pages :
1269-1272
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 July 2009

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