Article (Scientific journals)
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
ESSER, Nathalie; Legrand, Sylvie; Piette, Jacques et al.
2014In Diabetes Research and Clinical Practice
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Keywords :
Type 2 diabetes; metabolic syndrome; inflammation; NLRP3 inflammasome; macrophages; insulin resistance; obesity
Abstract :
[en] It is recognized that a chronic low-grade inflammation and an activation of the immune system are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, liver, muscle and pancreas are themselves sites of inflammation in presence of obesity. An infiltration of macrophages and other immune cells is observed in these tissues associated with a cell population shift from an anti-inflammatory to a pro-inflammatory profile. These cells are crucial for the production of pro-inflammatory cytokines, which act in an autocrine and paracrine manner to interfere with insulin signaling in peripheral tissues or induce β-cell dysfunction and subsequent insulin deficiency. Particularly, the pro-inflammatory interleukin-1β is implicated in the pathogenesis of type 2 diabetes through the activation of the NLRP3 inflammasome. The objectives of this review are to expose recent data supporting the role of the immune system in the pathogenesis of insulin resistance and type 2 diabetes and to examine various mechanisms underlying this relationship. If type 2 diabetes is an inflammatory disease, anti-inflammarory therapies could have a place in prevention and treatment of type 2 diabetes.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
ESSER, Nathalie  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Legrand, Sylvie ;  Université de Liège - ULiège > GIGA-R : Virologie - Immunologie
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie
SCHEEN, André  ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
PAQUOT, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Language :
English
Title :
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
Publication date :
2014
Journal title :
Diabetes Research and Clinical Practice
ISSN :
0168-8227
eISSN :
1872-8227
Publisher :
Elsevier Scientific, Limerick, Ireland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 May 2014

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