Article (Scientific journals)
Long-term fluvastatin reduces the hazardous effect of renal impairment on four-year atherosclerotic outcomes (a LIPS substudy)
Lemos, P. A.; Serruys, P. W.; de Feyter, P. et al.
2005In American Journal of Cardiology, 95 (4), p. 445-451
Peer Reviewed verified by ORBi
 

Files


Full Text
lemos 2005 long term fluvastatin.pdf
Publisher postprint (164.93 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Mild renal impairment is an important risk factor for late cardiovascular complications. This substudy of the Lescol Intervention Prevention Study (LIPS) assessed the effect of fluvastatin on outcome of patients who had renal dysfunction and those who did not. Complete data for creatinine clearance calculation. (Cockcroft=Gault formula) were available for 1,558 patients (92.9% of the LIPS population). Patients were randomized to fluvastatin or placebo after successful completion of a first percutaneous coronary intervention. Follow-up time was, 3 to 4 years. The effect of baseline creatinine clearance on coronary atherosclerotic events (cardiac death, non-fatal myocardial infarction, and coronary reinterventions not related to restenosis) was evaluated. Baseline creatinine clearance (logarithmic transformation) was inversely associated with an incidence of adverse events among patients who received, placebo. (hazard ratio 0.99, 95% confidence interval 0.982 to 0.998, p = 0.01). However, no association was noted between creatinine clearance and the incidence of adverse events among patients who received fluvastatin (hazard ratio 1.0, 95% confidence interval 0.99 to 1.0, p = 0.63). No further deterioration in creatinine clearance was observed during follow-up; regardless of baseline renal function or allocated treatment. Occurrence of adverse events was not related to changes in renal function during follow-up. Fluvastatin therapy markedly decreased the risk of coronary atherosclerotic events after percutaneous intervention in: patients who had lower values of creatinine clearance at baseline: The benefit of fluvastatin was unrelated to any effect on renal function. (C) 2005 by Excerpta Medica Inc.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Lemos, P. A.
Serruys, P. W.
de Feyter, P.
Mercado, N. F.
Goedhart, D.
Saia, F.
Arampatzis, C. A.
Soares, P. R.
Ciccone, M.
Arquati, M.
Cortellaro, M.
Rutsch, W.
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
More authors (3 more) Less
Language :
English
Title :
Long-term fluvastatin reduces the hazardous effect of renal impairment on four-year atherosclerotic outcomes (a LIPS substudy)
Publication date :
15 February 2005
Journal title :
American Journal of Cardiology
ISSN :
0002-9149
eISSN :
1879-1913
Publisher :
Excerpta Medica Inc, New York, United States - New York
Volume :
95
Issue :
4
Pages :
445-451
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 May 2014

Statistics


Number of views
116 (0 by ULiège)
Number of downloads
271 (0 by ULiège)

Scopus citations®
 
39
Scopus citations®
without self-citations
39
OpenCitations
 
28

Bibliography


Similar publications



Contact ORBi