[en] The aim of this multicenter pilot study was to evaluate the acute safety and efficacy of the dexamethasone-eluting stent (0.5 mug/mm(2) of stent) implanted in patients with de novo single-vessel disease. This study included 71 patients, 42% of whom had unstable angina pectoris. An appropriately sized BiodivYsio Matrix Lo stent loaded with a total dexamethasone dose of 0.5 mug/mm(2) of stent was used. Technical device success rate was 95%. Six-month MACE occurred in two patients (3.3%). Binary restenosis rate was 13.3%. Late loss was 0.45. Late loss and percent diameter stenosis were lower in the unstable angina pectoris patients compared to the stable patients (0.32 +/- 0.39 vs. 0.60 +/- 0.55 mm, P < 0.07, and 26.86 +/- 14 vs. 38.40 +/- 16%, P < 0.02). This study demonstrated the feasibility and safety of the implantation of a dexamethasone-eluting stent and its effect on in-stent neointimal hyperplasia. (C) 2003 Wiley-Liss, Inc.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Liu, X. S.
Huang, Y. M.
Hanet, C.
Vandormael, M.
Legrand, Victor ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Dens, J.
Vandenbossche, J. L.
Missault, L.
Vrints, C.
De Scheerder, I.
Language :
English
Title :
Study of antirestenosis with the BiodivYsio dexamethasone-eluting stent (STRIDE): A first-in-human multicenter pilot trial
Publication date :
October 2003
Journal title :
Catheterization and Cardiovascular Interventions
ISSN :
1522-1946
eISSN :
1522-726X
Publisher :
Wiley Liss, Inc., New York, United States - New York
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