Article (Scientific journals)
Multiple roles of Hoxc8 in skeletal development
Juan, A. H.; Lei, H. Y.; Bhargava, P. et al.
2006In Annals of the New York Academy of Sciences, 1068, p. 87-94
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Keywords :
Hoxc8; axial skeleton; osteoblast; Wnt; BMP
Abstract :
[en] We are interested in investigating the function of Hoxc8 in skeletogenesis during mouse development. Previous studies have shown that deregulation of Hoxc8 expression in the mouse leads to several skeletal defects, such as homeotic transformation in the thoracic vertebrae, abnormal development of the rib cage, and overproliferation of chondrocytes in the hypertrophic area. By deleting a crucial enhancer of Hoxc8 in vivo, we found that precise temporal expression of Hoxc8 is important for determining the correct identity of the vertebral column in early embryos. We also identified downstream targets of Hoxc8 relevant to osteoblast differentiation at later developmental stages.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Juan, A. H.
Lei, H. Y.
Bhargava, P.
Lebrun, Marielle  ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie et immunologie
Ruddle, F. H.
Language :
English
Title :
Multiple roles of Hoxc8 in skeletal development
Publication date :
2006
Journal title :
Annals of the New York Academy of Sciences
ISSN :
0077-8923
eISSN :
1749-6632
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Special issue title :
Skeletal Development and Remodeling in Health, Disease, and Aging
Volume :
1068
Pages :
87-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 May 2014

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