Article (Scientific journals)
Effect of Ketoconazole 1% and 2% Shampoos on Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments
Pierard-Franchimont, Claudine; Pierard, Gérald; Arrese, J. E. et al.
2001In Dermatology, 202 (2), p. 171-6
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Abstract :
[en] Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was carried out to differentiate the effectiveness of KET 1% and 2% in severe dandruff and seborrhoeic dermatitis. A total of 66 patients with severe dandruff or seborrhoeic dermatitis were randomized to each of the two groups. A 2-week run-in phase was followed by a 4-week treatment phase, in turn followed by a 4-week follow-up. The efficacy of treatments was evaluated by combining squamometry X, Malassezia spp. counts and clinical assessments. After 2 and 4 weeks of treatment, KET 2% was significantly superior over KET 1% (p < 0.001) for decreasing both in flakiness and Malassezia density from baseline. The same trend was observed in the mean change from baseline in the overall dandruff severity score. Only 6 mild adverse events were reported. During follow-up KET 2% showed a trend to fewer relapses than KET 1%. KET 2% had superior efficacy compared to KET 1% in the treatment of severe dandruff and scalp seborrhoeic dermatitis. Biometrological evaluations were correlated with the clinical improvements and therefore useful to incorporate in future dandruff studies.
Disciplines :
Dermatology
Author, co-author :
Pierard-Franchimont, Claudine ;  Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie
Pierard, Gérald ;  Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie
Arrese, J. E.
De Doncker, P.
Language :
English
Title :
Effect of Ketoconazole 1% and 2% Shampoos on Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments
Publication date :
2001
Journal title :
Dermatology
ISSN :
1018-8665
eISSN :
1421-9832
Publisher :
Karger, Basel, Switzerland
Volume :
202
Issue :
2
Pages :
171-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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