Reference : Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apopt...
Scientific journals : Article
Human health sciences : Oncology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/1666
Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis
English
Lechanteur, Chantal mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Greimers, Roland mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Benoit, Valérie [> > > >]
Deregowski, Valérie [> > > >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Merville, Marie-Paule mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Bours, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine]
3-Mar-2005
Oncogene
Nature Publishing Group
24
10
1788-1793
Yes (verified by ORBi)
International
0950-9232
London
[en] hypoxia ; apoptosis ; daunomycin ; colorectal cancer ; Akt ; Bad
[en] Hypoxia, a common feature of solid tumors, is a direct stress that triggers apoptosis in many cell types. Poor or irregular tumor vascularization also leads to a decreased drug diffusion and cancer cells distant from blood vessels (hypoxic cells) are exposed to low drug concentrations. In this report, we show that low daunomycin concentrations protect HCT116 colorectal cancer cells from hypoxia-induced apoptosis. While hypoxia induced p53 accumulation without expression of its responsive genes (bax and p21), daunomycin treatment restored p53 transactivation activity and cell cycle progression. We also demonstrated a role for Akt activation in daunomycin-induced protection through phosphorylation and inactivation of the Bcl-2 family proapoptotic factor Bad. Our data therefore suggest that chemotherapy could possibly, because of low concentrations in poorly vascularized tumors, protect cancer cells from hypoxia-induced cytotoxicity.
Giga-Signal Transduction
FNRS, TELEVIE, ARC ULG
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/1666
10.1038/sj.onc.1208436

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