[en] We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T-lymphocyte proliferation, NK activity, chemotaxis and phagocytosis of neutrophils. Training and competitions did not produce any change in the total number of leucocytes but increased neutrophil counts and decreased T4 lymphocyte counts. We also observed a slight decrease of T-lymphocyte proliferation and a significant decrease of neutrophil functions. On the other hand, training and competitions did not induce significant changes in the number of NK cells nor in the total NK cytotoxic activity. The different change observed tended to normalize after the sports season. Our results suggest a predominant neutrophil function depression in football players during a training season which could partly explain the susceptibility of elite athletes to infections.
Disciplines :
Orthopedics, rehabilitation & sports medicine Cardiovascular & respiratory systems Immunology & infectious disease
Author, co-author :
Bury, Thierry ; Université de Liège - ULiège > Département des sciences de la motricité > Physiologie humaine et physiologie de l'effort physique
Marechal, R.
Mahieu, P.
Pirnay, Freddy ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Immunological Status of Competitive Football Players During the Training Season
Bai Z, Kantorski J, Majewska E, Zeman K, Pokoca L, Fornalczyk E. Immunological status of competitive cyclists before and after the training season. Int J Sports Med 1994; 15: 319-24
Benoni G, Bellavite R, Adami A, Chirumbolo S, Lippi G, Brocco G, Giulini G, Cuzzolin L. Changes in several neutrophil functions in basketball players, before, during and after the sports season. Int J Sports Med 1995; 16: 34-7
Bollinger P, Drewinko B, Brailas C, Smeeton N, Trujillo J. The Technicon H1 - an automated hematology analyser for today and tomorrow. Am J Clin Pathol 1987; 87: 71-8
Bosenberg A, Brock-Utne J, Gaffin S, Wells M, Blake C. Strenuous exercise causes systemic endotoxemia. J Appl Physiol 1988, 65: 106-8
Boyden S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med 1962; 115: 453-6
Bury T, Corhay JL, Radermecker MF. Histamine-induced inhibition of neutrophil chemotaxis and T-lymphocyte proliferation in man. Allergy 1992; 47: 624-9
Bury T, Louis R, Radermecker M, Pirnay F. Blood mononuclear cells mobilization and cytokines secretion during prolonged exercises. Int J Sports Med 1996; 17: 156-60
Deuster PA, Curiale AM, Cowan ML, Finkelman FD. Exercise-induced changes in populations of peripheral blood mononuclear cells. Med Sci Sports Exerc 1988; 20: 276-80
Dufaux B, Order V. Complement activation after prolonged exercise. Clin Chim Acta 1989; 179: 45-50
Eskola J, Ruuskanen O, Soppi E, Viljanen M, Jarvinen M, Toivonen H, Kouvalainen K. Effect of sport stress on lymphocyte transformation and antibody formation. Clin Exp Immunol 1978; 32: 339-45
Gmunder F, Lorenzi G, Bechler B, Joller P, Muller J, Ziegler W, Cogoli A. Effects of long-term physical exercise on lymphocyte reactivity: similarity to spaceflight reactions. Aviat Space Environ Med 1988; 59: 146-51
Keast D, Cameron K, Morton AR. Exercise and the immune response. Sports Med 1988; 5: 248-67
Lewicki R, Tchorzewski H, Denys A, Kowalska M, Golinska A. Effect of physical exercise on some parameters of immunity in conditioned sportsmen. Int J Sports Med 1987; 8: 309-14
Linde F. Running and upper respiratory tract infections. Scan J Sports Sci 1987; 9: 21-3
Mackinnon L. Exercise and natural killer cells - What is the relationship? Sports Med 1989; 7: 141-9
Ndon J, Snyder A, Foster C, Wehrenberg W. Effects of chronic intense exercise training on the leucocyte response to acute exercise. Int J Sports Med 1992; 13: 176-82
Nieman D, Johanssen L, Lee J, Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 1990; 30: 316-28
Nieman D, Nehlsen-Cannarella S, Markoff P, Balk-Lamberton A, Yang H, Chritton D, Lee J, Arabatzis K. The effects of moderate exercise training in natural killer cells and acute upper respiratory tract infections. Int J Sports Med 1990; 11: 467-73
Nieman D, Miller A, Henson D, Warren B, Gusewitch G, Johnson R, Davis J, Butterworth D, Nehlsen-Cannarella S. Effects of high -vs moderate - intensity exercise on natural killer cell activity. Med Sci Sports Exerc 1993; 25: 1126-34
Nieman D. Exercise, upper respiratory tract infection and the immune system. Med Sci Sports Exerc 1994; 26: 128-39
Nieman D. Exercise, infection and immunity. Int J Sports Med 1994; 15: 131-41
Oshida Y, Yamanouchi K, Kayamizu Y, Sato Y. Effect of acute physical exercise on lymphocyte subpopulations in trained and untrained subjects. Int J Sports Med 1988; 9: 137-40
Peter E, Baterman E. Ultramarathon running and upper respiratory tract infections. S Afr Med J 1983; 64: 582-4
Peter E. Exercise, immunology and upper respiratory tract infections. Int J Sports Med 1997; 18: 69-77
Pyne D, Baker M, Fricker P, Mc Donald W, Telford R, Weideman M. Effects of an intensive 12 wk training program by elite swimmers on neutrophil oxidative activity. Med Sci Sports Exerc 1995; 27: 536-42
Sibille Y, Marchandise F. Pulmonary immune cells in health and disease: polymorphonuclear neutrophils. Eur Respir J 1993; 6: 1529-43
Smith J, Telford R, Mason I, Weidemann M. Exercise, training and neutrophil microbicidal activity. Int J Sports Med 1990; 11: 179-87
Smith J. Neutrophils, host defence and inflammation: a double-edged sword. J Leuk Biol 1994; 56: 672-86
Surkina I, Denilenko N, Dudov N, Gotovtesa O, Koptelov L, Kostina O, Vatagina A, Vorobiev A, Utchakin P. The role of the immune system in processes of adaptation to stress in sportsmen. Clin Sci 1994; 87: 22-30
Trippestad A, Midtvedt T. Phagocytosis of 32P-labelled E. Coli by rat peritoneal polymorphonuclear leucocytes. Evaluation of a method. Acta Path Microbiol Scand 1968: 74: 259-73