Méthodes d'évaluation et analyse des résultats à propos d'un essai clinique du Noveril simple et du Noveril TR

"Ordinary" Noveril was compared with timed-release Noveril in a 6-wk double-blind crossover trial. Ss were divided into 2 groups--one with 11 depressed patients and the other with 9 depressed patients--and were evaluated by the Hamilton Rating Scale for depression, the Breulet Depression Scale, the Cattell Anxiety Scale, and the MMPI. There were no significant differences between groups at the beginning of treatment. At the end of 3 wks, both groups had improved, but Ss on "ordinary" Noveril improved more. Some of the effects gained at the end of 3 wks were lost at the end of 6 wks in both groups. It is concluded that both forms of Noveril possess antidepressant activity, but that the "ordinary" form is more potent than the timed-release form. (English summary) (PsycINFO Database Record (c) 2012 APA, all rights reserved)