Reference : Theoretical and Experimental Investigations of Organic Acids/Cyclodextrin Complexes and ...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/1654
Theoretical and Experimental Investigations of Organic Acids/Cyclodextrin Complexes and Their Consequences Upon the Formation of Miconazole/Cyclodextrin/Acid Ternary Inclusion Complexes
English
Barillaro, Valéry [> > > >]
Dive, Georges mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Bertholet, Pascal [> > > >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Delattre, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Frederich, Michel mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Ziemons, Eric mailto [Université de Liège - ULg > > Chimie analytique >]
Piel, Géraldine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
22-Jan-2008
International Journal of Pharmaceutics
Elsevier Science Ltd
347
1-2
62-70
Yes (verified by ORBi)
International
0378-5173
Amsterdam
The Netherlands
[en] Acids ; Cyclodextrins ; ROESY experiments ; Molecular modeling ; Normal mode ; FT-IR ; Supercritical carbon dioxide ; AM1 calculations
[en] (1)H NMR spectrometry, FT-IR spectroscopy, as well as molecular modeling at the AM1 level and normal mode analysis were used to characterise the interactions and the formation of inclusion complexes between three organic acids: maleic, fumaric, L-tartaric acids and betaCD. In aqueous medium, the complexation was confirmed by (1)H NMR spectroscopy using two-dimensional technique. The stable geometries of the complexes were determined by molecular modeling. Experimental infrared frequencies were assigned on the base of the vibrational normal mode calculation at the fully optimized geometry for the inclusion complexes. All the results point out the presence of stable inclusion complexes between acids and betaCD at the solid state. These results show the double role of the acid. Correlated with the theoretical and experimental data previously obtained for the miconazole/CD/acids complexes, in function of both acids and CDs structures, the acids can either stabilize the complexes by formation of a multicomponent complex or form acid/CD inclusion complexes, hindering the guest inclusion.
C.I.R.M.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/1654
10.1016/j.ijpharm.2007.06.030

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
IntJPharm_VBarillaro_2008_1.pdfPublisher postprint657.59 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.