Article (Scientific journals)
Translocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis.
Herens, Christian; Hermanne, Jean-Philippe; Tassin, Françoise et al.
1999In Cancer Genetics and Cytogenetics, 110 (1), p. 62-4
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Keywords :
Aged; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 3; Humans; Male; Primary Myelofibrosis/genetics; Translocation, Genetic
Abstract :
[en] Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom translocation involves a pluripotent stem cell and is associated with a poor prognosis.
Disciplines :
Hematology
Genetics & genetic processes
Author, co-author :
Herens, Christian ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Hermanne, Jean-Philippe;  Centre Hospitalier Universitaire de Liège - CHU
Tassin, Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Fassotte, Marie-France ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Thiry, Albert ;  Université de Liège - ULiège > Anatomie pathologique
Jamar, Mauricette ;  Université de Liège - ULiège > Génétique
Schaaf-Lafontaine, Nicole ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Fillet, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Koulischer, Lucien ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Translocation (2;3)(p21;q26) as the sole anomaly in a case of primary myelofibrosis.
Publication date :
1999
Journal title :
Cancer Genetics and Cytogenetics
ISSN :
0165-4608
eISSN :
1873-4456
Publisher :
Elsevier Science, New York, United States - New York
Volume :
110
Issue :
1
Pages :
62-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 31 March 2009

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