Article (Scientific journals)
Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injury
Kaux, Jean-François; Janssen, Lauriane; Drion, Pierre et al.
2014In Muscles, Ligaments and Tendons Journal, 4 (1 (eCollection 2014 Jan)), p. 25-28
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Keywords :
biomechanical; growth factor; healing, tendon; VEGF; VEGF-111
Abstract :
[en] Tendon lesions are among the most frequent musculoskeletal pathologies. Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. This study aimed at evaluating whether VEGF-111 could have a therapeutic interest in tendon pathologies. Surgical section of one Achilles tendon of rats was performed before a local injection of either saline or VEGF-111. After 5, 15 and 30 days, the Achilles tendons of 10 rats of both groups were sampled and submitted to a biomechanical tensile test. The force necessary to induce tendon rupture was greater for tendons of the VEGF-111 group (p<0.05) while the section areas of the tendons were similar. The mechanical stress was similar at 5 and 15 days in the both groups but was improved for the VEGF-111 group at day 30 (p <0.001). No difference was observed in the mRNA expression of collagen III, tenomodulin and MMP-9. In conclusion, we observed that a local injection of VEGF-111 improves the early phases of the healing process of rat tendons after a surgical section. Further confirmatory experimentations are needed to consolidate our results.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Kaux, Jean-François  ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Janssen, Lauriane ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Drion, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
Nusgens, Betty ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Libertiaux, Vincent
Pascon, Frédéric
HEYERES, Antoine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
HOFFMANN, Audrey ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Lambert, Charles ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
LE GOFF, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Denoël, Vincent  ;  Université de Liège - ULiège > Département ArGEnCo > Analyse sous actions aléatoires en génie civil
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Rickert, Markus
Crielaard, Jean-Michel ;  Université de Liège - ULiège > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques
Colige, Alain ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
More authors (5 more) Less
Language :
English
Title :
Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injury
Publication date :
May 2014
Journal title :
Muscles, Ligaments and Tendons Journal
eISSN :
2240-4554
Publisher :
C.I.C. Edizioni Internazionali srl, Italy
Volume :
4
Issue :
1 (eCollection 2014 Jan)
Pages :
25-28
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 31 March 2014

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