[en] Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or identical to those of its skeletal muscle counterpart and other M-type lactate dehydrogenases. A model involving a dual oxidative-anaerobic metabolism of the icefish heart is proposed.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Feller, Georges ; Université de Liège - ULiège > Département des sciences de la vie > Labo de biochimie
Pauly, J. P.
Smal, A.
O'Carra, P.
Gerday, Charles ; Université de Liège - ULiège > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences)
Language :
English
Title :
The Lactate Dehydrogenase of the Icefish Heart: Biochemical Adaptations to Hypoxia Tolerance
