Reference : A New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Oncology
http://hdl.handle.net/2268/16433
A New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells
English
Grooteclaes, Madeleine mailto [> > > >]
Vernimmen, Douglas [> > > >]
Plaza, S. [> > > >]
Pasleau, Françoise mailto [Université de Liège - ULg > CARE "Le Réseau des bibliothèques de l'ULg" > Bibliothèque des Sciences de la vie >]
Hodzic, Didier [> > > >]
Winkler-Gol, Rose mailto [> > > >]
1-Jun-1999
Cancer Research
59
11
2527-31
Yes (verified by ORBi)
International
0008-5472
[en] The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene transcription. We report the identification of a new 17-bp-long cis sequence located between positions -506 and -489 from the transcription start site. This sequence is recognized by a trans-activating factor that we tentatively named HER2 transcription factor (HTF). This factor, involved in the increased transcription of the HER2 gene in the BT-474 mammary tumor cells, has a molecular weight of about Mr 50,000. HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. Interestingly, the HTF binding activity is high in nuclear extracts from several mammary tumor cells overexpressing the HER2 gene.
Researchers ; Professionals
http://hdl.handle.net/2268/16433

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.