|Reference : A New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells|
|Scientific journals : Article|
|Life sciences : Biochemistry, biophysics & molecular biology|
Human health sciences : Oncology
|A New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells|
|Grooteclaes, Madeleine [> > > >]|
|Vernimmen, Douglas [> > > >]|
|Plaza, S. [> > > >]|
|Pasleau, Françoise [Université de Liège - ULg > CARE "Le Réseau des bibliothèques de l'ULg" > Bibliothèque des Sciences de la vie >]|
|Hodzic, Didier [> > > >]|
|Winkler-Gol, Rose [> > > >]|
|[en] The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene transcription. We report the identification of a new 17-bp-long cis sequence located between positions -506 and -489 from the transcription start site. This sequence is recognized by a trans-activating factor that we tentatively named HER2 transcription factor (HTF). This factor, involved in the increased transcription of the HER2 gene in the BT-474 mammary tumor cells, has a molecular weight of about Mr 50,000. HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. Interestingly, the HTF binding activity is high in nuclear extracts from several mammary tumor cells overexpressing the HER2 gene.|
|Researchers ; Professionals|
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