ORBi: Colinet Frédéric - Genomic location of the bovine growth hormone secretagogue receptor (Ghsr) gene and investigation of genetic polymorphism

Reference : Genomic location of the bovine growth hormone secretagogue receptor (Ghsr) gene and inve...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Animal production & animal husbandry Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/2268/16400

Title :	Genomic location of the bovine growth hormone secretagogue receptor (Ghsr) gene and investigation of genetic polymorphism
Language :	English
Author, co-author :	Colinet, Frédéric [Faculté Universitaire des Sciences Agronomiques de Gembloux - FUSAGx > > Biologie animale et microbienne > >]
	Vanderick, Sylvie [Université de Liège - ULg > Sciences agronomiques > Zootechnie >]
	Charloteaux, Benoît [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér. >]
	Eggen, André [Institut Scientifique de Recherche Agronomique - INRA > > >UR339 Laboratoire de Génétique Biochimique et Cytogénétique > > >]
	Gengler, Nicolas [Université de Liège - ULg > Sciences agronomiques > Zootechnie >]
	Renaville, Bénédicte [>University of Udine > > >Veterinary Physiology and Nutrition Unit > > >]
	Brasseur, Robert [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie moléc. et numér. >]
	Portetelle, Daniel [Université de Liège - ULg > Chimie et bio-industries > Biologie animale et microbienne >]
	Renaville, Robert [Université de Liège - ULg > Chimie et bio-industries > Biologie animale et microbienne >]
Publication date :	2009
Journal title :	Animal Biotechnology
Publisher :	Taylor & Francis Group
Volume :	20
Issue/season :	1
Pages :	28-33
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1049-5398
City :	Philadelphia
Country :	PA
Keywords :	[en] Cattle ; GHSR ; Polymorphism
Abstract :	[en] The growth hormone secretagogue receptor (GHSR) is involved in the regulation of energetic homeostasis and GH secretion. In this study, the bovine GHSR gene was mapped to BTA1 between BL26 and BMS4004. Two different bovine GHSR CDS (GHSR1a and GHSR1b) were sequenced. Six polymorphisms (five SNPs and one 3-bp indel) were also identified, three of them leading to amino acid variations L24V, D194N, and Del R242. These variations are located in the extracellular N-terminal end, the exoloop 2, and the cytoloop 3 of the receptor, respectively.
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/16400
DOI :	10.1080/10495390802602926

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