Altered network properties of the fronto-parietal network and the thalamus in impaired consciousness

[en] Recovery of consciousness has been associated with connectivity in the frontal cortex and parietal regions modulated by the thalamus. To examine this model and to relate alterations to deficits in cognitive functioning and conscious processing, we investigated topological network properties in patients with chronic disorders of consciousness recovered from coma. Resting state fMRI data of 34 patients with unresponsive wakefulness syndrome and 25 in minimally conscious state were compared to 28 healthy controls.We investigated global and local network characteristics. Additionally, behavioralmeasureswere correlatedwith the localmetrics of 28 regionswithin the fronto-parietal network and the thalamus. In chronic disorders of consciousness, modularity at the global level was reduced suggesting a disturbance in the optimal balance between segregation and integration.Moreover, network properties were altered in several regionswhich are associatedwith conscious processing (particularly, inmedial parietal, and frontal regions, aswell as in the thalamus). Between minimally conscious and unconscious patients the local efficiency of medial parietal regions differed. Alterations in the thalamus were particularly evident in non-conscious patients.Most of the regions affected in patientswith impaired consciousness belong to the so-called ‘rich club’ of highly interconnected central nodes. Disturbances in their topological characteristics have severe impact on information integration and are reflected in deficits in cognitive functioning probably leading to a total breakdown of consciousness.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Crone, Julia Sophia

Soddu, Andrea ; Université de Liège - ULiège > Centre de recherches du cyclotron

Höller, Yvonne

Vanhaudenhuyse, Audrey ; Université de Liège - ULiège > Centre de recherches du cyclotron

Schurz, Matthias

Bergmann, Jürgen

Schmid, Elisabeth

Trinka, Eugen

Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron

Kronbichler, Martin

Language :

English

Title :

Altered network properties of the fronto-parietal network and the thalamus in impaired consciousness

Publication date :

2014

Journal title :

NeuroImage: Clinical

eISSN :

2213-1582

Publisher :

Elsevier

Pages :

240-248

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science/article/pii/S2213158213001642

Available on ORBi :

since 09 March 2014

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176 (8 by ULiège)

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Scopus citations^®

109

Scopus citations^®
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