Reference : Identification of protein biomarkers associated with cardiac ischemia by a proteomic ...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/163324
Identification of protein biomarkers associated with cardiac ischemia by a proteomic approach.
English
Fillet, Marianne mailto [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
Deroyer, Céline [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments >]
COBRAIVILLE, G. [Université de Liège - ULg > Département de pharmacie > Analyse des médicaments > >]
LE GOFF, Caroline mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Cavalier, Etienne mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Marée, Raphaël mailto [Université de Liège - ULg > > GIGA-Management : Plateforme bioinformatique >]
Legrand, Victor mailto [Université de Liège - ULg > Département des sciences cliniques > Cardiologie >]
Pierard, Luc mailto [Université de Liège - ULg > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
Merville, Marie-Paule mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
2013
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
18
7
614-24
Yes (verified by ORBi)
International
1354-750X
1366-5804
England
[en] Angina is chest pain induced by ischemia of the heart muscle, generally due to obstruction or spasm of the coronary arteries. People that suffer from average to severe cases of angina have an increased percentage of death before the age of 55, usually around 60%. Therefore, prevention of major complications, optimizing diagnosis, prognosis and therapeutics are of primary importance. The main objective of this study was to uncover biomarkers by comparing serum protein profiles of patients suffering from stable or unstable angina and controls. We identified by non-targeted proteomic approach and confirmed by the means of independent techniques, the differential expression of several proteins indicating significantly increased vascular inflammation response, disturbance in the lipid metabolism and in atherogenic plaques stability.
http://hdl.handle.net/2268/163324
10.3109/1354750X.2013.838306

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