Article (Scientific journals)
Identification of protein biomarkers associated with cardiac ischemia by a proteomic approach.
Fillet, Marianne; Deroyer, Céline; COBRAIVILLE, Gaël et al.
2013In Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 18 (7), p. 614-24
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Abstract :
[en] Angina is chest pain induced by ischemia of the heart muscle, generally due to obstruction or spasm of the coronary arteries. People that suffer from average to severe cases of angina have an increased percentage of death before the age of 55, usually around 60%. Therefore, prevention of major complications, optimizing diagnosis, prognosis and therapeutics are of primary importance. The main objective of this study was to uncover biomarkers by comparing serum protein profiles of patients suffering from stable or unstable angina and controls. We identified by non-targeted proteomic approach and confirmed by the means of independent techniques, the differential expression of several proteins indicating significantly increased vascular inflammation response, disturbance in the lipid metabolism and in atherogenic plaques stability.
Disciplines :
Biochemistry, biophysics & molecular biology
Cardiovascular & respiratory systems
Author, co-author :
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Deroyer, Céline  ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
COBRAIVILLE, Gaël ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
LE GOFF, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Chapelle, Jean-Paul ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Marée, Raphaël  ;  Université de Liège - ULiège > GIGA-Management : Plateforme bioinformatique
Legrand, Victor ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Pierard, Luc ;  Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Kolh, Philippe  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path.
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Identification of protein biomarkers associated with cardiac ischemia by a proteomic approach.
Publication date :
2013
Journal title :
Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
ISSN :
1354-750X
eISSN :
1366-5804
Publisher :
Taylor & Francis, United Kingdom
Volume :
18
Issue :
7
Pages :
614-24
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 February 2014

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