Article (Scientific journals)
Adenoid Hepatocellular Carcinoma Accompanied by Uncharacterized Eosinophilic Intracytoplasmic Inclusions in a Green Iguana (Iguana iguana)
Schilliger, Lionel; Selleri, Paolo; Gandar, Frederic et al.
2012In Journal of Herpetological Medicine and Surgery, 22 (3-4), p. 70-75
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Keywords :
adenoid hepatocellular carcinoma; green iguana; Iguana iguana; inclusion bodies; liver; neoplasm
Abstract :
[en] An adult, 2.9 kg, 4-year-old female green iguana, Iguana iguana, was examined for anorexia, weight loss, and lethargy. Physical examination revealed a dull integument, minimal pelvic and tailbase adipose deposits, and a distended coelom. Bilateral renal enlargement was identified on intracloacal digital palpation. Complete blood count and serum biochemistry results indicated hepatic and renal disease. Radiographs and ultrasound revealed severe liver enlargement and ascites. Exploratory coeliotomy revealed a massive and diffusely enlarged liver with rounded margins and a smooth capsular surface, indicative of an infiltrative process. Due to poor prognosis, the owner requested that the animal be euthanized. A diagnosis of acinar hepatocellular carcinoma was made on histopathological evaluation of liver tissue collected after euthanasia. Eosinophilic intracytoplasmic inclusion bodies, surrounded by clear halos, were seen in a few neoplastic cells. Several malignant hepatic tumors have been previously reported in reptiles; however, this case report documents the first reptilian adenoid hepatocellular carcinoma associated with intracytoplasmic eosinophilic inclusions in neoplastic hepatocytes.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Schilliger, Lionel;  Clinique Vétérinaire du Village d'Auteuil, Paris
Selleri, Paolo;  Clinica per Animali Esotici, Rome
Gandar, Frederic ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine des oiseaux, des lagomorphes et des rongeurs
Rival, Franck;  Clinique Vétérinaire de l'Arche, Valence
Bonwitt, Jesse;  University of Bristol
Frye, Fredric
Language :
English
Title :
Adenoid Hepatocellular Carcinoma Accompanied by Uncharacterized Eosinophilic Intracytoplasmic Inclusions in a Green Iguana (Iguana iguana)
Publication date :
September 2012
Journal title :
Journal of Herpetological Medicine and Surgery
ISSN :
1529-9651
Publisher :
Association of Reptilian and Amphibian Veterinarians, Chester Heights, United States - Pennsylvania
Volume :
22
Issue :
3-4
Pages :
70-75
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2014

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