Article (Scientific journals)
Disorders of consciousness after acquired brain injury: the state of the science
Giacino, Joseph T; Fins, Joseph J; Laureys, Steven et al.
2014In Nature Reviews. Neurology
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Abstract :
[en] The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain injury results in the dissolution of consciousness, providing a natural model from which key insights about consciousness may be drawn. In the clinical setting, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate through word or gesture, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate and inappropriate care. In this Review, we describe the state of the science with regard to clinical management of patients with prolonged disorders of consciousness. We review consciousness-altering pathophysiological mechanisms, specific clinical syndromes, and novel diagnostic and prognostic applications of advanced neuroimaging and electrophysiological procedures. We conclude with a provocative discussion of bioethical and medicolegal issues that are unique to this population and have a profound impact on care, as well as raising questions of broad societal interest.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Giacino, Joseph T
Fins, Joseph J
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Schiff, Nicholas D
Language :
English
Title :
Disorders of consciousness after acquired brain injury: the state of the science
Publication date :
2014
Journal title :
Nature Reviews. Neurology
ISSN :
1759-4758
eISSN :
1759-4766
Publisher :
Nature Publishing Group, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 February 2014

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