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Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy
Tosi, Irène; Art, Tatiana; Cassart, Dominique et al.
2013Association Vétérinaire Equine Française (AVEF)
 

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Abstract :
[en] Introduction: Exertional rhabdomyolyses are a common cause of exercise intolerance in the equine athlete, and Polysaccharide Storage Myopathy (PSSM) is a widely described muscular pathology. It is characterized by an accumulation of abnormal glycogen in myofibers due to a genetic defect in the skeletal muscle glycogen synthase (GYS1) enzyme. We hypothesized that the energetic production through the oxidative phosphorylation (OXPHOS) in muscular mitochondria might be impaired in type-1 PSSM-affected horses. Material and Methods: Eight horses with a history of exertional rhabdomyolysis were tested for the GYS1 mutation. Muscle biopsies were collected and used for histological analysis and high resolution respirometry (HRR). HRR values from 3 groups of horses (PSSM-positive horses, horses with a history of myopathy but negative to PSSM and healthy controls) were compared using a linear mixed model to take into account repeated (2-3 times) measurements made for each horse. Results: In four horses histology revealed an accumulation of abnormal glycogen in myofibers. A severe depression of the maximal OXPHOS capacity was observed by HRR in all horses with exertional rhabodmyolysis, with lower values in PSSM-positive cases. Conclusions: Our study shows a severe decreased OXPHOS capacity in PSSM-affected horses. PSSM is considered primarily a defect in glycogen synthesis but altered OXPHOS might play a central role in its pathogenesis.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Tosi, Irène ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux
Art, Tatiana ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux
Cassart, Dominique ;  Université de Liège - ULiège > Département de morphologie et pathologie > Département de morphologie et pathologie
Serteyn, Didier  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Votion, Dominique  ;  Université de Liège - ULiège > Scientifiques attachés au Doyen (F MV)
Language :
English
Title :
Altered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy
Publication date :
2013
Event name :
Association Vétérinaire Equine Française (AVEF)
Event place :
Deauville, France
Event date :
11 décembre 2013 au 13 décembre 2013
Audience :
International
Available on ORBi :
since 09 February 2014

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