Article (Scientific journals)
Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium
Reis, N.; Gonçalves, C. N.; Aguedo, Mario et al.
2006In Biotechnology Letters, 28 (7), p. 485-490
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Keywords :
Micro-bioreactor; Mixing; Oscillatory flow; Screening; Two immiscible liquid phases; Yarrowia lipolytica; Gamma; Mass transfer rates; Reactor geometry; Biotechnology; Productivity; Bioreactors; Yarrowia; Cell Culture Techniques; Culture Media; Emulsions; Equipment Design; Equipment Failure Analysis; Feasibility Studies; Lactones; Mechanotransduction, Cellular; Microfluidic Analytical Techniques; Oscillometry; Phase Transition; Solutions
Abstract :
[en] A novel micro-bioreactor based on the oscillatory flow technology was applied to the scale-down of the biotechnological production of γ-decalactone. A decrease up to 50% of the time required to obtain the maximum concentration of the compound was observed, when compared with other scaled-down platforms (stirred tank bioreactor or shake flask). A three-fold increase in γ-decalactone productivity was obtained by increasing oscillatory mixing intensity from Re o ∼482 to Re o ∼1447. This was presumably related to the effective contribution of the reactor geometry to enhanced mass transfer rates between the two immiscible liquid phases involved in the process by increasing the interfacial area. © Springer 2006.
Disciplines :
Biotechnology
Author, co-author :
Reis, N.;  Centro de Engenharia Biológica, Universidade Do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Gonçalves, C. N.;  Centro de Engenharia Biológica, Universidade Do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Aguedo, Mario ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Gomes, N.;  Centro de Engenharia Biológica, Universidade Do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Teixeira, J. A.;  Centro de Engenharia Biológica, Universidade Do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Vicente, A.;  Centro de Engenharia Biológica, Universidade Do Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Language :
English
Title :
Application of a novel oscillatory flow micro-bioreactor to the production of γ-decalactone in a two immiscible liquid phase medium
Publication date :
2006
Journal title :
Biotechnology Letters
ISSN :
0141-5492
eISSN :
1573-6776
Publisher :
Kluwer Academic Publishers, Netherlands
Volume :
28
Issue :
7
Pages :
485-490
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 February 2014

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