Article (Scientific journals)
Patients' preferences for osteoporosis drug treatment: a discrete-choice experiment.
Hiligsmann, Mickaël; Dellaert, Benedict G.; Dirksen, Carmen D. et al.
2014In Arthritis Research and Therapy, 16 (1), p. 36
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Abstract :
[en] INTRODUCTION: The patient's perspective is becoming increasingly important in clinical and policy decisions. In this study, we aimed to evaluate the preferences of patients with, or at risk of, osteoporosis for medication attributes, and to establish how patients trade between these attributes. METHODS: A discrete choice experiment survey was designed and patients were asked to choose between two hypothetical unlabelled drug treatments (and an opt-out option) that vary in five attributes: efficacy in reducing the risk of fracture, type of potential common side-effects, mode and frequency of administration and out-of-pocket costs. An efficient experimental design was used to construct the treatment option choice sets and a mixed logit panel data model was used to estimate patients' preferences and trade-offs between attributes. RESULTS: A total of 257 patients with, or at risk of, osteoporosis completed the experiment. As expected, patients preferred treatment with higher effectiveness and lower cost. They also preferred either an oral monthly tablet or 6-month subcutaneous injection above weekly oral tablets, 3-month subcutaneous, 3-month intravenous or yearly intravenous injections. Patients disliked being at risk of gastro-intestinal disorders more than being at risk of skin reactions and flu-like symptoms. There was significant variation in preferences across the sample for all attributes except subcutaneous injection. CONCLUSIONS: This study revealed that osteoporotic patients preferred 6-month subcutaneous injection and oral monthly tablet, and disliked gastro-intestinal disorders. Moreover, patients were willing to pay a personal contribution or to trade treatment efficacy for better levels of other attributes. Preferences for treatment attributes varied across patients and this highlights the importance of clinical decision-making taking individual preferences into account to improve osteoporosis care.
Disciplines :
General & internal medicine
Author, co-author :
Hiligsmann, Mickaël ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Dellaert, Benedict G.
Dirksen, Carmen D.
van der Weijden, Trudy
Goemaere, Stefan
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Watson, Verity
Boonen, Annelies
Language :
English
Title :
Patients' preferences for osteoporosis drug treatment: a discrete-choice experiment.
Publication date :
2014
Journal title :
Arthritis Research and Therapy
ISSN :
1478-6354
eISSN :
1478-6362
Publisher :
BioMed Central, London, United Kingdom
Volume :
16
Issue :
1
Pages :
R36
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 February 2014

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