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Poster (Scientific congresses and symposiums)
Drug delivery systems based on amphiphilic polyphosphate-copolymers
Vanslambrouck, Stéphanie; Clement, Benoît; Riva, Raphaël et al.
2013Annuel PAI Meeting
 

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Keywords :
ring-opening polymerization (ROP); cyclic phosphate; biomaterial; nanomedicine
Abstract :
[en] Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromoleculesn such as nucleic acids, polyphosphates (PPhos) are of prime interest as biomaterials. In contrast to poly--caprolactone and polylactides, PPhos properties and functionality are easily tuned via the nature of the pendant group of the starting cyclic monomer. For example, by varying the length of the alkyl chain the hydrophobicity of the PPhos can be adjusted. In this work, an efficient organo-catalytic system was developed to synthesize a series of amphiphilic diblock copolymers, i.e. poly(ethylene oxide)-b-polyphosphate (PEO-b-PPhos) by ring-opening polymerization of cyclic phosphates. This novel approach prevents metallic residues to polute the final product, and which is highly desirable when biomedical applications are foreseen. For drug delivery application, the micellization of these novel diblock copolymers in aqueous media was investigated, as well as, encapsulation of an hydrophobic drug. Data on, the influence of the polyphosphate nature of the polymer on drug loading will be presented.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Vanslambrouck, Stéphanie ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Clement, Benoît ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Riva, Raphaël ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Ucakar, Bernard;  Université Catholique de Louvain (UCL) > Louvain Drug Research Institute > Pharmaceutics and Drug Delivery
Préat, Véronique;  Université Catholique de Louvain (UCL) > Louvain Drug Research Institute > Pharmaceutics and Drug Delivery
Koole, Leo H.;  Maastricht University > Center for Biomaterials Research
Molin, Daniel G. M.;  Maastricht University > Center for Biomaterials Research
Broze, Guy ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lecomte, Philippe  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Drug delivery systems based on amphiphilic polyphosphate-copolymers
Publication date :
18 September 2013
Event name :
Annuel PAI Meeting
Event place :
Ghent, Belgium
Event date :
18/09/2013
Funders :
BioMiMedics
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
This poster was presented by Stéphanie Vanslambrouck
Available on ORBi :
since 30 January 2014

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