Article (Scientific journals)
Le trouble bipolaire: une affection bien complexe.
PITCHOT, William; Scantamburlo, Gabrielle; Ansseau, Marc et al.
2012In Revue Médicale de Liège, 67 (5-6), p. 366-373
Peer reviewed
 

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Keywords :
Animals; Bipolar Disorder/epidemiology/etiology/genetics/therapy; Causality; Disease Susceptibility; Environment; Gene-Environment Interaction; Humans; Risk Factors
Abstract :
[en] Bipolar disorder is a multifactorial disease with a strong genetic component. However, environmental factors also play a role in the onset of the disease and in manic and depressive recurrence. The onset of the disorder is the consequence of a complex interaction between genetic and environmental factors. This gene-environment interaction is well illustrated by the influence of childhood trauma on the clinical expression of the disease in terms of age of onset, comorbidity and suicide. The complexity and heterogeneity of bipolar disorder require the identification of homogenous sub-groups with the use of biomarkers that could help reduce the etiological heterogeneity and better target the therapeutical options.
Disciplines :
Psychiatry
Author, co-author :
PITCHOT, William ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Scantamburlo, Gabrielle ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Souery, D
Language :
French
Title :
Le trouble bipolaire: une affection bien complexe.
Alternative titles :
[en] Bipolar disorder: a multifactorial disease
Publication date :
2012
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
67
Issue :
5-6
Pages :
366-373
Peer reviewed :
Peer reviewed
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since 30 January 2014

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