Reference : Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/16238
Frontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease
English
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Van der Linden, Martial mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Delrue, Gaël mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
2002
Alzheimer Disease and Associated Disorders
Lippincott Williams & Wilkins
16
4, Oct-Dec
228-238
Yes (verified by ORBi)
International
0893-0341
Philadelphia
[en] inhibition ; frontal lobe ; disconnection ; cerebral metabolism
[fr] démence sénile ; lobes frontaux ; cerveau ; inhibition
[en] A series of tasks assessing inhibitory processes was administered to patients with Alzheimer disease and control subjects. Two groups of patients with Alzheimer disease were examined: patients with hypometabolism restricted to the posterior (temporal and parietal) cerebral areas and patients with hypometabolism in both posterior and anterior (frontal) cerebral areas. The performances of the patients with Alzheimer disease were inferior to those of control subjects on all inhibitory tasks, but the two groups of patients obtained similar scores. These data indicate that frontal lobe hypometabolism is not necessary to produce inhibitory impairment in Alzheimer disease. Consequently, inhibitory dysfunction could be the consequence of a (partial) disconnection process between posterior and anterior cerebral areas.
Centre de Recherches du Cyclotron - CRC
Researchers
http://hdl.handle.net/2268/16238
http://www.lww.com/resources/permissions/index.html

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