Article (Scientific journals)
The neglected intrinsic resistome of bacterial pathogens.
Fajardo, Alicia; Martinez-Martin, Nadia; Mercadillo, Maria et al.
2008In PLoS ONE, 3 (2), p. 1619
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Keywords :
Anti-Bacterial Agents/pharmacology; DNA Transposable Elements; Drug Resistance, Bacterial/genetics; Genes, Bacterial/genetics; Genome, Bacterial; Mutation; Pseudomonas aeruginosa/drug effects/genetics
Abstract :
[en] Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature.
Disciplines :
Microbiology
Author, co-author :
Fajardo, Alicia
Martinez-Martin, Nadia
Mercadillo, Maria
Galan, Juan C.
Ghysels, Bart ;  Vrije Universiteit Brussel - VUB > Laboratory if Microbial Interactions
Matthijs, Sandra
Cornelis, Pierre
Wiehlmann, Lutz
Tummler, Burkhard
Baquero, Fernando
Martinez, Jose L.
Language :
English
Title :
The neglected intrinsic resistome of bacterial pathogens.
Publication date :
2008
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, United States - California
Volume :
3
Issue :
2
Pages :
e1619
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 January 2014

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