|Reference : Platelet-rich plasma (PRP) increases healing process of rats' Achilles tendons|
|Scientific congresses and symposiums : Unpublished conference|
|Human health sciences : Orthopedics, rehabilitation & sports medicine|
|Platelet-rich plasma (PRP) increases healing process of rats' Achilles tendons|
|Kaux, Jean-François [Université de Liège - ULg > Département des sciences de la motricité > Médecine physique et réadaptation fonctionnelle >]|
|Drion, Pierre [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]|
|Pascon, Frédéric [Université de Liège - ULg > Département Argenco : Secteur GEO3 > Géomécanique et géologie de l'ingénieur >]|
|Libertiaux, Vincent [Université de Liège - ULg > Département Argenco : Secteur MS2F > Mécanique des solides >]|
|Le Goff, Caroline [Université de Liège - ULg > > Chimie médicale >]|
|Gothot, André [Université de Liège - ULg > > Hématologie biologique et immuno hématologie >]|
|Cescotto, Serge [Université de Liège - ULg > Département Argenco : Secteur MS2F > Mécanique des solides >]|
|Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]|
|Rickert, Markus [> >]|
|Crielaard, Jean-Michel [Université de Liège - ULg > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques - Médecine physique et réadaptation fonctionnelle >]|
|VVS Biennial Congress for Sports Medicine and Sports Sciences|
|Vlaamse Vereniging voor Sportgeneeskunde en Sportwetenschappen|
|[en] PRP ; Tendon ; rat|
Some tendinopathies (epicondylitis, jumper’s knee or Achilles tendinopathy) are frequently considered as rebel to “classic” treatments such as rest, orthotics, NSAIs, electrotherapy, physiotherapy, corticosteroid infiltrations, extracorporeal shock waves… Recently, several studies, essentially in vitro, demonstrated the positive effects of platelets on the healing process of different tissues: bones, muscles and tendons.
The aim of our experiment was to ascertain whether the use of platelet-rich plasma (PRP) was of interest for accelerating the healing process of Achilles tendon after surgical induced lesion.
A 5mm defect was surgically induced in rat Achilles tendon after resection of plantaris tendon. Rats were divided into 2 groups: A: control (no injection) and B: PRP injection. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cage without immobilization. After 5, 15 and 30 days, rats were euthanized. The traumatized Achilles tendon of each rat was removed and dissected during this healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”.
We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile test study was more important for tendons which had been submitted to an injection of PRP. These results were noticed from day 5 onwards.
Discussion – Conclusion
This experimentation has shown that PRP injections could accelerate tendons healing process and increase the force needed to break tendons in their healing process. This “accelerating” process can be observed as early as day 5.
This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants.
|Researchers ; Professionals|
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