Article (Scientific journals)
Heat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers
Liu, Ji; Detrembleur, Christophe; De Pauw-Gillet, Marie-Claire et al.
2014In Journal of Materials Chemistry B, 2 (1), p. 59-70
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Keywords :
biomaterial; nanomedicine
Abstract :
[en] Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous cavities, while phase-change molecules (PCMs), e.g. 1-tetradecanol (TD) with a melting temperature (Tm) of 39 °C, were introduced as gatekeepers to regulate the release behaviours. An overall loading amount of ca. 20 wt% (TD/DOX ca. 50/50 wt/wt) was confirmed. Heat-triggered release of DOX evidenced a “zero premature release” (<3% of the entire payload in 96 h release) under physiological conditions (37°C), and however, a sustainable release (ca. 40% of the entire payload in 96 h) above Tm of TD (40 °C). It also demonstrated the possibility to deliver drug payloads in small portions (pulsatile release mode) via multiple heating on/off cycles, due to the reversible phase change of the PCMs. In vitro heattriggered release of DOX within cell culture of the MEL-5 melanoma cell line was also tested. It was found that DOX molecules were trapped efficiently within the mesopores even after internalization within the cytoplasm of MEL-5 cells at 37 °C, with the potential toxicity of DOX strongly quenched (>95% viability after 72 h incubation). However, continuous cell apoptosis was detected at cell culture temperature above Tm of TD, due to the heat-triggered release of DOX (<50% viability after 72 h incubation at 40 °C). Moreover, due to the presence of a maghemite core within the DDS, T2-weighted magnetic resonance imaging performance was also confirmed. These as-designed core–shell nanoparticles are envisaged to become promising DDS for “on-demand” heat-triggered release.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Liu, Ji ;  Université de Liège - ULiège, University of Bordeaux, CNRS > Department of Chemistry (Liège), ICMCB (Bordeaux) > Center for Education and Research on Macromolecules (CERM, Liège)
Detrembleur, Christophe ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
De Pauw-Gillet, Marie-Claire ;  Université de Liège - ULiège > Laboratory of Mammalian Cell Culture (GIGA-R)
Mornet, Stéphane;  University of Bordeaux, CNRS > ICMCB
Vander Elst, Luce;  University of Mons-Hainaut (UMH) > Department of General, Organic & Biomedical Chemistry > NMR & Molecular Imaging
Laurent, Sophie;  University of Mons-Hainaut (UMH) > Department of General, Organic & Biomedical Chemistry > NMR & Molecular Imaging
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Duguet, Etienne;  University of Bordeaux, CNRS > ICMCB
Language :
English
Title :
Heat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers
Publication date :
07 January 2014
Journal title :
Journal of Materials Chemistry B
ISSN :
2050-750X
eISSN :
2050-7518
Publisher :
Royal Society of Chemistry, United Kingdom
Volume :
2
Issue :
1
Pages :
59-70
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
The Erasmus Mundus international doctoral school IDS-FunMat
Available on ORBi :
since 21 January 2014

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