Article (Scientific journals)
La Narcolepsie-Cataplexie aujourd'hui
DEPIERREUX, Frédérique; FANIELLE, Julien; Lecomte, Marianne et al.
2014In Revue Médicale de Liège, 69 (2), p. 72-81
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Keywords :
Narcolepsy-cataplexy; Hypocretin; Orexin; Sodium-Oxybate; Diagnosis; Treatment; Diagnostic; Traitement; Narcolepsie-cataplexie; Hypocrétine; Orexine
Abstract :
[en] Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue Médicale de Liège, in 2002, is based, in human beings, <br />on a destruction of specific cells located in the lateral and <br />posterior part of the hypothalamus (the perifornical nuclei, <br />containing some 70,000 neurons), producing peptides which <br />stimulate the central nervous system; they are called hypocretins <br />or orexins. The role of autoimmunity in their disappearance <br />becomes more evident. The treatment is simplified but <br />remains symptomatic. It is mainly based on Sodium Oxybate <br />or Gamma-Hydroxybutyrate, syrup, prescribed for the night. <br />The authors report on their own experience in this regard and <br />on future therapeutics more targeted towards the cause of the <br />disease.
Research center :
CHU de Liège, service de neurologie
Disciplines :
Neurology
Author, co-author :
DEPIERREUX, Frédérique  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
FANIELLE, Julien ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Lecomte, Marianne ;  Université de Liège > Département des sciences cliniques > Département des sciences cliniques
HANS, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
MAQUET, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
POIRRIER, Robert ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Language :
French
Title :
La Narcolepsie-Cataplexie aujourd'hui
Alternative titles :
[en] Narcolepsy-Cataplexy Today
Publication date :
2014
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
69
Issue :
2
Pages :
72-81
Peer reviewed :
Peer reviewed
Available on ORBi :
since 06 January 2014

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