ORBi: Kinet Virginie - Antiangiogenic liposomal gene therapy with 16K human prolactin efficiently reduces tumor growth.

Reference : Antiangiogenic liposomal gene therapy with 16K human prolactin efficiently reduces tumor...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/16059

Title :	Antiangiogenic liposomal gene therapy with 16K human prolactin efficiently reduces tumor growth.
Language :	English
Author, co-author :	Kinet, Virginie [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Nguyen, Ngoc-Quynh-Nhu [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Sabatel, Céline [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Blacher, Silvia [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Martial, Joseph [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
	Struman, Ingrid [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Publication date :	2009
Journal title :	Cancer Letters
Publisher :	Elsevier Science Ireland
Volume :	284
Issue/season :	2
Pages :	222-228
Audience :	International
ISSN :	0304-3835
e-ISSN :	1872-7980
City :	Limerick
Country :	Ireland
Abstract :	[en] Human 16K PRL (16K hPRL) is a potent inhibitor of angiogenesis both in vitro and in vivo. It has been shown to prevent tumor growth in three xenograft mouse models. Here we have used a gene transfer method based on cationic liposomes to produce 16K hPRL and demonstrate that 16K hPRL inhibits tumor growth in a subcutaneous B16F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in the reduction of tumor vessel length and width, leading to a 57% reduction in average vessel size. We thus show, for the first time, that administration of the 16K hPRL gene complexed to cationic liposomes is effective to maintain antiangiogenic activities of 16K hPRL level.
Permalink :	http://hdl.handle.net/2268/16059
DOI :	10.1016/j.canlet.2009.04.030

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