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Dermatological manifestations of varicella
EL HAYDERI, Lara; NIKKELS, Arjen
2013In Berhardt, Leon V. (Ed.) Advances in Medicine and Biology
 

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Keywords :
Varicella zoster virus; skin lesions; VZV
Abstract :
[en] The Varicella zoster virus (VZV) is responsible for chickenpox and herpes zoster (HZ). VZV displays neuro- and epidermotropism, although other cells lines may be infected. A permissive type of VZV infection in the epidermal and/or infundibular keratinocytes forms the majority of the skin lesions. This infections leads to intra-epidermal blistering, clinically characterized by vesicular lesions. During varicella, the haematogenous dissemination of VZV virions infects the dermal endothelial cells, which in their turn infect dermal dendrocytes who transport he virions to the keratinocytes of the basal layer. During HZ, the VZV virions arrive in the keratinocytes after release by the free nerve endings in close contact with the basal keratinocytes. The skin-associated immune system (SALT) furthermore determines the outcome of the virus/host cell relation. The spectrum of the VZV-related skin infections is presented with their pathogenic mechanisms, including lichenoid HZ, granulomatous HZ, verrucous HZ and follicular HZ. It is important to be aware of these manifestations of the VZV, in particular as VZV may present serious morbidity int eh immunocompromised patient.
Disciplines :
Dermatology
Author, co-author :
EL HAYDERI, Lara ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
NIKKELS, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Language :
English
Title :
Dermatological manifestations of varicella
Publication date :
2013
Main work title :
Advances in Medicine and Biology
Editor :
Berhardt, Leon V.
Publisher :
Nova Science Publishers, Inc, New York, United States
Pages :
95-110
Available on ORBi :
since 23 December 2013

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