Article (Scientific journals)
Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury
Williams, Shawniqua; Conte, Mary; Goldfine, Andrew et al.
2013In eLife
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Keywords :
Zolpidem
Abstract :
[en] Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subjects with severe brain injury but underlying mechanisms remain unknown. In three diverse patients with known zolpidem responses we identify a distinctive pattern of EEG dynamics that suggests a mechanistic model. In the absence of zolpidem, all subjects show a strong low frequency oscillatory peak ∼6–10 Hz in the EEG power spectrum most prominent over frontocentral regions and with high coherence (∼0.7–0.8) within and between hemispheres. Zolpidem administration sharply reduces EEG power and coherence at these low frequencies. The ∼6–10 Hz activity is proposed to arise from intrinsic membrane properties of pyramidal neurons that are passively entrained across the cortex by locally-generated spontaneous activity. Activation by zolpidem is proposed to arise from a combination of initial direct drug effects on cortical, striatal, and thalamic populations and further activation of underactive brain regions induced by restoration of cognitively-mediated behaviors.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Williams, Shawniqua
Conte, Mary
Goldfine, Andrew
Noirhomme, Quentin ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Gosseries, Olivia  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Thonnard, Marie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Beattie, Bradley
Hersh, Jennifer
Katz, Douglas
Victor, Jonathan
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Schiff, Nicholas
Language :
English
Title :
Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury
Publication date :
19 November 2013
Journal title :
eLife
eISSN :
2050-084X
Publisher :
eLife Sciences Publications, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 December 2013

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