Article (Scientific journals)
Lung function and airway inflammation monitoring after hematopoietic stem cell transplantation.
Moermans, Catherine; Poulet, Christophe; HENKET, Monique et al.
2013In Respiratory Medicine, 107, p. 2071-2080
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Keywords :
hematopoietic stem cell transplantation; lung function; sputum; exhaled nitric oxide
Abstract :
[en] Background Induced sputum is a non-invasive method to investigate airway inflammation, which has been used to assess pulmonary inflammatory diseases. However, this procedure has not been studied in the context of hematopoietic stem cell transplantation (HSCT). Methods We monitored lung function in 182 patients who underwent HSCT and measured airway inflammation by sputum induction in 80 of them. We prospectively measured FEV1, FVC, DLCO, KCO, TLC, RV, exhaled nitric oxide (FeNO) as well as sputum cell counts before and 3, 6, 12, 24 and 36 months after HSCT. Results For the whole cohort there was a progressive decrease in TLC, which was significant after 3 years (p < 0.01). By contrast, there was no change in other lung functions parameters or in FeNO. Baseline sputum analysis revealed increased neutrophil counts in patients {Median (IQR): 63% (38–79)} compared to healthy subjects matched for age {Median (IQR): 49% (17–67), p < 0.001} but there was no significant change in any type of sputum cell counts over the three years. When comparing myeloablative (MA) vs non-myeloablative (NMA) conditioning, falls in FEV1, FVC and DLCO, and rise in RV and sputum neutrophils were more pronounced over the first year of observation in those receiving MA. Conclusions There was a progressive loss in lung function after HSCT, featuring a restrictive pattern. Myeloablative conditioning was associated with early rise of sputum neutrophils and greater alteration in lung function over the first year.
Disciplines :
Hematology
Author, co-author :
Moermans, Catherine  ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Poulet, Christophe  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
HENKET, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Bonnet, Christophe ;  Université de Liège - ULiège > GIGA-R : Hématologie
WILLEMS, Evelyne ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Baron, Frédéric  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
English
Title :
Lung function and airway inflammation monitoring after hematopoietic stem cell transplantation.
Publication date :
2013
Journal title :
Respiratory Medicine
ISSN :
0954-6111
eISSN :
1532-3064
Publisher :
W.B. Saunders, London, United Kingdom
Volume :
107
Pages :
2071-2080
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 December 2013

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