Article (Scientific journals)
Phenolic acid-rich extract of sweet basil restores cholesterol and triglycerides metabolism in high fat diet-fed mice: A comparison with fenofibrate
Harnafi, H.; Ramchoun, M.; Tits, Monique et al.
2013In Biomedicine and Preventive Nutrition, 3 (4), p. 393-397
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Keywords :
Atherogenic index; Hypolipidemia; Mice; Ocimum basilicum; Phenolic acids
Abstract :
[en] Many spices are often added to foods as additives to enhance organoleptic qualities, such as flavor, aroma and color. Sweet basil (Ocimum basilicum L.) family of Lamiaceae is widely used in cooking for its culinary attributes. In this study, we aimed at the investigation of the hypocholesterolemic and hypotriglyceridemic activities of the basil phenolic acid-rich extract in high fat diet-induced hyperlipemic mice. Hyperlipemia was developed by a high fat diet containing cholesterol, lard and cholic acid. At the beginning of the experiment, animals were divided into three groups, one of them served as normolipidemic control group (NCG), the second hyperlipidemic control group (HCG) and the third basil-treated group (BTG). After 5 weeks of treatment, basil phenolic acid-rich extract significantly decreased plasma total cholesterol, triglycerides and LDL-cholesterol (-42%,-42% and -86%, respectively, P < 0.001). However, HDL-cholesterol was increased (+79%, P < 0.001). The extract reduced the atherogenic index and LDL/HDL-C ratio (-88% and -94%, respectively, P < 0.001). The reductions of liver total cholesterol and triglycerides were of -50% (P < 0.01) and -58% (P < 0.01), respectively. The hypolipemic effect of the phenolic acid-rich extract is comparable to that exerted by fenofibrate. This drug significantly reduced plasma total cholesterol, triglycerides and LDL-cholesterol (-25.5%, -51%, and -83.5%, respectively, P < 0.001) and increased plasma HDL-cholesterol (+136%, P < 0.001). On the other hand, fenofibrate significantly decreased atherogenic index and LDL/HDL-cholesterol ratio (-91% and -93%, respectively, P < 0.001). The fenofibrate decreased hepatic total cholesterol by 59.5% and triglycerides by 72%, respectively (P < 0.01). HPLC analysis led to identify four major compounds: caftaric acid, cafeic acid, chicoric acid and rosmarinic acid. In conclusion, the Sweet basil contains phenolic products that are able to lower hyperlipidemia and prevent atherosclerosis. © 2013 Elsevier Masson SAS. All rights reserved.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Harnafi, H.;  Laboratoire de valorisation et sécurité des produits agroalimentaires, Faculté des sciences et techniques, 23000 Béni-Mellal, Morocco
Ramchoun, M.;  Département de biologie, Faculté des sciences, 60000 Oujda, Morocco
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Wauters, Jean-Noël ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Aziz, M.;  Département de biologie, Faculté des sciences, 60000 Oujda, Morocco
Alem, C.;  Département de biologie, Faculté des sciences et techniques, 52000 Errachidia, Morocco
Amrani, S.;  Département de biologie, Faculté des sciences, 60000 Oujda, Morocco
Language :
English
Title :
Phenolic acid-rich extract of sweet basil restores cholesterol and triglycerides metabolism in high fat diet-fed mice: A comparison with fenofibrate
Publication date :
2013
Journal title :
Biomedicine and Preventive Nutrition
eISSN :
2210-5239
Publisher :
Elsevier Masson, France
Volume :
3
Issue :
4
Pages :
393-397
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 December 2013

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