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Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline; Nasir, Mehmet Nail; Nott, Katherine et al.
2013In World Academy of Science, Engineering and Technology, 77, p. 840
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Keywords :
Aromatic glycolipids; monolayer models; membrane models; antioxidant
Abstract :
[en] Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed.
Disciplines :
Biochemistry, biophysics & molecular biology
Chemistry
Author, co-author :
Sainvitu, Pauline ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Nasir, Mehmet Nail ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Nott, Katherine ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Lins, Laurence  ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Crowet, Jean-Marc ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Nicks, françois
Laurent, Pascal
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Cosse, Jean-Philippe ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Jérôme, Christine  ;  Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)
Deleu, Magali  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Language :
English
Title :
Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Alternative titles :
[fr] Caractérisation biophysique des interactions de nouveaux surfactants aromatiques glycolipidiques avec des membranes modèles.
Publication date :
May 2013
Event name :
ICBCBBE 2013 : International Conference on Bioinformatics, Computational Biology and Biomedical Engineering
Event organizer :
World Academy of Science, Engineering and Technology (WASET)
Event place :
Amsterdam, Netherlands
Event date :
15-16 may 2013
By request :
Yes
Audience :
International
Journal title :
World Academy of Science, Engineering and Technology
ISSN :
2010-376X
eISSN :
2010-3778
Publisher :
World Academy of Science, Engineering and Technology, Las Cruces, United States - New Mexico
Special issue title :
Amsterdam May 2013
Volume :
77
Pages :
840
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 November 2013

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